Department of Chemistry, University of Louisville, Louisville, Kentucky 40292, USA.
Org Lett. 2011 Jul 1;13(13):3450-3. doi: 10.1021/ol2011902. Epub 2011 Jun 2.
Using a readily available secondary aminoalkyne as starting material, a powerful strategy was discovered to prepare precursors of biologically important unnatural cyclic aminoacids and fluorinated N-heterocycles with important ring sizes (e.g., 5-7) in a one-pot reaction using two nucleophilic additions in a tandem fashion.
利用易得的仲二级炔烃作为起始原料，通过两步串联亲核加成反应一锅法，发现了一种强有力的策略，可用于制备具有重要环尺寸（例如 5-7）的生物重要非天然环状氨基酸和氟化 N-杂环的前体。
