通过铜催化烯胺活化合成环状α-氨基膦酸酯
Synthesis of Cyclic α-Aminophosphonates through Copper Catalyzed Enamine Activation.
作者信息
Han Junbin, Paton Robert S, Xu Bo, Hammond Gerald B
机构信息
Department of Chemistry, University of Louisville, Louisville, KY 40292, USA.
Chemistry Research Laboratory, University of Oxford, Mansfield Road, Oxford OX1 3TA, UK.
出版信息
Synthesis (Stuttg). 2013 Feb 1;45(4):463-470. doi: 10.1055/s-0032-1317984.
Abstract
A copper-catalyzed tandem cyclization triggered addition strategy that relies on electrophilic enamine activation has been used to synthesize various cyclic α-aminophosphonates derivatives in good to excellent yields. Both five and six membered rings can be generated under mild conditions with high regioselectivity. A mechanism based on copper catalyzed enamine activation is proposed.
摘要
一种基于亲电烯胺活化的铜催化串联环化引发加成策略已被用于以良好至优异的产率合成各种环状α-氨基膦酸酯衍生物。在温和条件下可以高区域选择性地生成五元环和六元环。提出了一种基于铜催化烯胺活化的机理。
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