Servicio de Medicina Interna, Hospital Universitario de Canarias, La Laguna, Tenerife, Spain.
Alcohol Alcohol. 2011 Sep-Oct;46(5):529-33. doi: 10.1093/alcalc/agr064. Epub 2011 Jun 2.
Interleukin (IL)-15 is highly expressed in skeletal muscle, where it exerts anabolic effects, increasing protein content in muscle fibres and promoting muscle growth. Alcoholics frequently suffer myopathy. Therefore, we analyse the behaviour of IL-15 (and other myokines, such as IL-6, IL-8 and tumour necrosis factor α (TNF-α)) in alcoholics.
These myokines and also malondialdehyde (MDA)--a lipid peroxidation product--were determined by radioimmunoanalytic techniques in blood samples of 35 chronic alcoholics and 13 age- and sex-matched controls, and compared with body composition, nutritional status, liver function, amount of ethanol and routine biochemical variables.
IL-15, IL-6, TNF-α, IL-8 and MDA were all higher in alcoholics than in controls; MDA and IL-6 were clearly related with liver function impairment and short-term prognosis, whereas IL-15 was higher among those who died and was related to serum bilirubin. No relation was found between IL-15 and lean mass.
IL-15 levels were higher in alcoholics than in controls, especially among those who died within 18 months after admission. They are not related with muscle mass, intensity of alcoholism or nutritional status, but only with serum bilirubin. IL-6 showed inverse correlations with liver function, intensity of alcoholism, nutritional status, left arm muscle mass and short-term mortality.
白细胞介素 (IL)-15 在骨骼肌中高度表达，具有合成代谢作用，增加肌纤维中的蛋白质含量并促进肌肉生长。酗酒者常患有肌病。因此，我们分析了酒精中毒患者中 IL-15（和其他肌因子，如 IL-6、IL-8 和肿瘤坏死因子 α (TNF-α)）的行为。
采用放射免疫分析技术测定 35 名慢性酗酒者和 13 名年龄和性别匹配的对照组的血液样本中的这些肌因子和丙二醛 (MDA)——一种脂质过氧化产物——并将其与身体成分、营养状况、肝功能、乙醇量和常规生化变量进行比较。
IL-15、IL-6、TNF-α、IL-8 和 MDA 在酗酒者中均高于对照组；MDA 和 IL-6 与肝功能损害和短期预后明显相关，而 IL-15 在死亡者中较高，与血清胆红素有关。IL-15 与瘦体重之间没有关系。
酗酒者的 IL-15 水平高于对照组，尤其是在入院后 18 个月内死亡的患者。它们与肌肉质量、酗酒强度或营养状况无关，而仅与血清胆红素有关。IL-6 与肝功能、酗酒强度、营养状况、左臂肌肉质量和短期死亡率呈负相关。
