Johns Hopkins University School of Medicine.
Blood. 2011 Jun 2;117(22):5788-90. doi: 10.1182/blood-2011-04-346668.
In this issue of Blood, Ikeda et al report the effects of the high mobility group A2 (Δhmga2) lacking the 3' untranslated region (UTR) in hematopoietic tissues. Overexpression of Δhmga2 in transgenic mice resulted in "big mice with big blood": the mice weighed more and had a myeloproliferative phenotype with increases in peripheral blood counts, splenomegaly, a hypercellular bone marrow and erythropoietin-independent erythroid colony formation.
在本期《Blood》中，池田等人报告了高迁移率族蛋白 A2（Δhmga2）缺失 3'非翻译区（UTR）在造血组织中的作用。在转基因小鼠中过表达Δhmga2 导致“大老鼠大血”：小鼠体重增加，具有骨髓增生性表型，外周血计数增加、脾肿大、骨髓细胞增多和红细胞生成素非依赖性红细胞集落形成。
