Departamento de Ciência e Tecnologia de Alimentos, Universidade Estadual de Londrina, Londrina, PR, Brazil.
Genet Mol Biol. 2011 Jan;34(1):131-5. doi: 10.1590/S1415-47572010005000103. Epub 2011 Mar 1.
Carboxymethyl-glucan (CM-G) is a soluble derivative from Saccharomyces cerevisiae (1 → 3)(1 → 6)-β-D-glucan. The protective efficiency of CM-G against DNA damage in cells from patients with advanced prostate cancer (PCa), and undergoing Androgen Deprivation Therapy (ADT), was evaluated. DNA damage scores were obtained by the comet assay, both before and after treatment with CM-G. The reduction in DNA damage, ranging from 18% to 87%, with an average of 59%, was not related to the increased number of leukocytes in peripheral blood. The results demonstrate for the first time the protective effect of CM-G against DNA damage in patients with advanced PCa. Among smokers, three presented the highest reduction in DNA damage after treatment with CM-G. There was no observable relationship between DNA damage scores before and after treatment, and age, alcoholism and radiotherapy.
羧甲基葡聚糖（CM-G）是一种来自酿酒酵母（1 → 3）（1 → 6）-β-D-葡聚糖的可溶性衍生物。评估了 CM-G 对接受雄激素剥夺治疗（ADT）的晚期前列腺癌（PCa）患者细胞中 DNA 损伤的保护效率。在使用 CM-G 进行治疗前后，通过彗星试验获得 DNA 损伤评分。DNA 损伤的减少范围从 18%到 87%，平均减少 59%，与外周血中白细胞数量的增加无关。结果首次证明了 CM-G 对晚期 PCa 患者 DNA 损伤的保护作用。在吸烟者中，有三人在接受 CM-G 治疗后 DNA 损伤的减少幅度最大。治疗前后的 DNA 损伤评分之间没有明显的关系，与年龄、酗酒和放疗也没有关系。
