Herman Tim, Morris Jennifer, Colton Shannon, Batiza Ann, Patrick Michael, Franzen Margaret, Goodsell David S
MSOE Center for BioMolecular Modeling, Milwaukee School of Engineering, Milwaukee, Wisconsin 53213.
Biochem Mol Biol Educ. 2006 Jul;34(4):247-54. doi: 10.1002/bmb.2006.494034042649.
The technology now exists to construct physical models of proteins based on atomic coordinates of solved structures. We review here our recent experiences in using physical models to teach concepts of protein structure and function at both the high school and the undergraduate levels. At the high school level, physical models are used in a professional development program targeted to biology and chemistry teachers. This program has recently been expanded to include two student enrichment programs in which high school students participate in physical protein modeling activities. At the undergraduate level, we are currently exploring the usefulness of physical models in communicating concepts of protein structure and function that have been traditionally difficult to teach. We discuss our recent experience with two such examples: the close-packed nature of an enzyme active site and the pH-induced conformational change of the influenza hemagglutinin protein during virus infection.
现在已有技术能够根据已解析结构的原子坐标构建蛋白质的物理模型。在此，我们回顾一下我们最近在高中和本科阶段使用物理模型教授蛋白质结构和功能概念方面的经验。在高中阶段，物理模型用于针对生物和化学教师的专业发展项目。该项目最近已扩大到包括两个学生拓展项目，高中生可参与蛋白质物理建模活动。在本科阶段，我们目前正在探索物理模型在传达传统上难以教授的蛋白质结构和功能概念方面的有用性。我们讨论最近在两个此类例子中的经验：酶活性位点的紧密堆积性质以及流感血凝素蛋白在病毒感染期间由pH诱导的构象变化。
