Jungck John R, Cebeci Metehan
Delaware Biotechnology Institute, University of Delaware, Newark, DE, USA.
Evol Bioinform Online. 2022 May 31;18:11769343221101014. doi: 10.1177/11769343221101014. eCollection 2022.
Wenxiang diagrams illustrate protein helices as spirals on a plane and thus have the advantage over helical wheels of being planar graphs. Wenxiang 3.0 extends the original version by adding 3 major features: (1) individual amino acid residues can be colored according to their evolutionary conservation in comparative multiple sequence alignments using CONSURF encoding; (2) α, π, and 3/10 helices can be illustrated by overlaying arcs representative of the pitches of these helices; and, (3) the physico-chemical properties of amino acids residues in the protein sequence can be re-presented by colored geometric shapes.
文祥图将蛋白质螺旋表示为平面上的螺旋线，因此作为平面图，它比螺旋轮具有优势。文祥3.0通过增加3个主要特征扩展了原始版本：（1）可以使用CONSURF编码，根据比较多序列比对中单个氨基酸残基的进化保守性对其进行着色；（2）通过叠加代表这些螺旋螺距的弧线，可以展示α、π和3/10螺旋；以及（3）蛋白质序列中氨基酸残基的物理化学性质可以用彩色几何形状重新呈现。
