Section of Gynaecological Endocrinology and Reproductive Medicine, University of Ulm, Prittwitzstrasse 43, Ulm, Germany.
Reprod Biomed Online. 2011 Jun;22(6):536-44. doi: 10.1016/j.rbmo.2011.02.006. Epub 2011 Feb 13.
The in-vitro culture of human embryos in a medium subjected to regular short intervals of mechanical agitation leads to increased development rates. This type of treatment tries to mimic conditions in nature whereby oviductal fluid is mechanically agitated by the epithelial cilia. This phenomenon can be explained by the fact that an embryo developing in vivo is naturally exposed to constant vibrations of around 6Hz with the periodically repeating increase to 20Hz. This review covers the history of this question and in this light offers an explanation through biological concept for one of the most recent developments in this area: in-vitro culture of human embryos with mechanical micro-vibration. The effect of mechanical micro-vibration on embryos during their in-vitro culture was examined. Pregnancy rates after the transfer of embryos in the group with in-vitro culture under mechanical vibration were increased.
将人类胚胎在经过定期短暂机械搅拌的培养基中进行体外培养会导致发育速度加快。这种处理方法试图模拟体内的情况，即输卵管中的液体被上皮纤毛进行机械搅拌。这种现象可以通过以下事实来解释：在体内发育的胚胎自然会受到约 6Hz 的持续振动的影响，并且会周期性地增加到 20Hz。这篇综述涵盖了这个问题的历史，并从生物学角度对这一领域的最新发展之一进行了解释：对人类胚胎进行机械微振动的体外培养。研究了机械微振动对体外培养胚胎的影响。在机械振动下进行体外培养的胚胎移植后的妊娠率有所提高。
