Department of Orthodontics, School of Dentistry, Oral Pathology and Maxillofacial Surgery, Faculty of Medicine, Catholic University of Leuven, Leuven, Belgium.
Am J Orthod Dentofacial Orthop. 2011 Jun;139(6):735-44. doi: 10.1016/j.ajodo.2009.10.043.
Bacterial plaque is an etiologic factor in the development of gingival inflammation and periodontitis. The presence of orthodontic bands and brackets influences plaque growth and maturation. The purposes of this research were to monitor microbiologic and periodontal changes after placement of orthodontic attachments over a 1-year period and to link these changes to alterations in cytokine concentrations in the gingival crevicular fluid (GCF).
This longitudinal split-mouth trial included 24 patients. Supragingival and subgingival plaque composition, probing depth, bleeding on probing, and GCF flow and composition were assessed at baseline (Tb) and after 1 year (T52). A statistical comparison was made over time and between the banded and bonded sites. Prognostic factors for the clinical reaction at T52 in the GCF at Tb were determined.
Between Tb and T52, the pathogenicity of the plaque and all periodontal parameters increased significantly, but intersite differences were not seen, except for bleeding on probing. The cytokine concentrations in the GCF did not differ significantly between the sites or between Tb and T52. The interleukin-6 concentration in the GCF at Tb was a significant predictive value for the GCF flow at T52 (P <0.05). The same relationship was found between the interleukin-8 concentration at Tb and the increase in probing depth at T52 (P <0.05).
Interleukin-6 and interleukin-8 concentrations before orthodontic treatment were shown to be significant predictive factors for some potential inflammatory parameters during treatment.
细菌菌斑是引发牙龈炎症和牙周炎的病因之一。正畸带环和托槽的存在会影响菌斑的生长和成熟。本研究的目的是在 1 年的时间内监测正畸附件放置后微生物学和牙周的变化，并将这些变化与龈沟液（GCF）中细胞因子浓度的变化联系起来。
本纵向分口试验纳入 24 名患者。在基线（Tb）和 1 年后（T52）评估龈上和龈下菌斑组成、探诊深度、探诊出血和 GCF 流量及成分。对时间和带环与粘结部位进行了统计学比较。确定 Tb 时 GCF 中 T52 临床反应的预后因素。
从 Tb 到 T52，菌斑的致病性和所有牙周参数显著增加，但未观察到部位间差异，除了探诊出血。GCF 中的细胞因子浓度在部位之间或 Tb 和 T52 之间无显著差异。Tb 时 GCF 中的白细胞介素-6 浓度是 GCF 流量在 T52 时的显著预测值（P<0.05）。在 Tb 时白细胞介素-8 浓度与 T52 时探诊深度增加之间也存在同样的关系（P<0.05）。
正畸治疗前的白细胞介素-6 和白细胞介素-8 浓度被证明是治疗期间某些潜在炎症参数的显著预测因子。
