Altındal Dicle, Tunca Yasemin, Tunca Murat
Angle Orthod. 2025 Mar 1;95(2):212-218. doi: 10.2319/050224-347.1.
To compare short-term changes in the levels of interleukin-8 (IL-8) and interleukin-6 (IL-6) in the gingival crevicular fluid (GCF) of individuals undergoing orthodontic treatment with clear aligners.
This study included 15 individuals. Each patient used clear aligners designed not to cause tooth movement in the GCF sampled teeth, to be changed every 10 days. GCF samples were collected from teeth 16 (upper right first molar) and 31 (lower left central incisor) at baseline and after the procedure at the first hour, third, seventh, 14th, and 21st days. In addition, clinical periodontal parameters for the full mouth and the teeth from which GCF was collected were recorded initially and on the 21st day.
A statistically significant difference was observed between the levels of IL-8 before the procedure, on the third and seventh days, and on the 21st day (P < .01). The increase in IL-6 levels on the 14th and 21st days was significantly different compared to the levels before the procedure (P < .01). A positive correlation was detected between IL-8 and IL-6 levels at the first hour, a negative correlation on the third day, and a lower level of positive correlation on the seventh, 14th, and 21st days.
Within 21 days, the levels of IL-8 and IL-6 significantly increased in individuals undergoing orthodontic treatment with clear aligners. Within the limits of this study, the clear aligner material may affect the levels of IL-8 and IL-6 in the GCF.
比较使用透明矫治器进行正畸治疗的个体龈沟液（GCF）中白细胞介素-8（IL-8）和白细胞介素-6（IL-6）水平的短期变化。
本研究纳入15名个体。每位患者使用设计为不会导致GCF采样牙齿发生牙齿移动的透明矫治器，每10天更换一次。在基线时以及在第1小时、第3天、第7天、第14天和第21天进行操作后，从16号牙（右上第一磨牙）和31号牙（左下中切牙）采集GCF样本。此外，在最初和第21天记录全口以及采集GCF样本的牙齿的临床牙周参数。
在操作前、第3天和第7天以及第21天的IL-8水平之间观察到统计学上的显著差异（P < .01）。与操作前的水平相比，第14天和第21天IL-6水平的升高有显著差异（P < .01）。在第1小时，IL-8和IL-6水平之间检测到正相关，在第3天为负相关，在第7天、第14天和第21天正相关水平较低。
在21天内，使用透明矫治器进行正畸治疗的个体中IL-8和IL-6水平显著升高。在本研究的范围内，透明矫治器材料可能会影响GCF中IL-8和IL-6的水平。
