University of São Paulo, Ribeirão Preto, São Paulo, Brazil.
Respir Med. 2011 Sep;105(9):1316-21. doi: 10.1016/j.rmed.2011.04.017.
The Flutter(®)VRP1 combines high frequency oscillation and positive expiratory pressure (PEP).
To separately evaluate the effect of the Flutter(®)VRP1 components (high frequency oscillation and PEP) on mucus transportability in patients with bronchiectasis.
Eighteen patients with bronchiectasis received sessions with the Flutter(®)VRP1 or PEP for 30 min daily in a randomized, crossover study. The treatment duration was four weeks with one of the therapies, one week of a "wash-out" period and followed by four more weeks with the other treatment. Weekly secretion samples were collected and evaluated for mucociliary relative transport velocity (RTV), displacement in a simulated cough machine (SCM) and contact angle measurement (CAM). For the proposed comparisons, a linear regression model was used with mixed effects with a significance level of 5%.
The Flutter(®)VRP1 treatment resulted in greater displacement in SCM and lower CAM when comparing results from the first (9.6 ± 3.4 cm and 29.4 ± 5.7°, respectively) and fourth weeks of treatment (12.44 ± 10.5 cm and 23.28 ± 6.2°, respectively; p < 0.05). There was no significant difference in the RTV between the treatment weeks for either the Flutter(®)VRP1 or PEP.
The use of the Flutter(®)VRP1 for four weeks is capable of altering the respiratory secretion transport properties, and this alteration is related to the high frequency oscillation component.
Flutter(®)VRP1 结合了高频振荡和呼气正压（PEP）。
分别评估 Flutter(®)VRP1 组件（高频振荡和 PEP）对支气管扩张症患者黏液输送能力的影响。
18 例支气管扩张症患者接受 Flutter(®)VRP1 或 PEP 治疗，每天 30 分钟，采用随机交叉研究。一种疗法治疗 4 周，“洗脱”期 1 周，然后再用另一种疗法治疗 4 周。每周收集分泌物样本，评估黏液相对输送速度（RTV）、模拟咳嗽机中的位移（SCM）和接触角测量（CAM）。对于所提出的比较，使用具有混合效应的线性回归模型，显著性水平为 5%。
与治疗第一周（9.6 ± 3.4 cm 和 29.4 ± 5.7°，分别）和第四周（12.44 ± 10.5 cm 和 23.28 ± 6.2°，分别）的结果相比，Flutter(®)VRP1 治疗导致 SCM 中更大的位移和更低的 CAM（p < 0.05）。在 Flutter(®)VRP1 或 PEP 的治疗周之间，RTV 没有显著差异。
使用 Flutter(®)VRP1 治疗 4 周能够改变呼吸分泌物的输送特性，这种改变与高频振荡成分有关。
