钙结合蛋白介导的电压门控钙通道调节与人类疾病相关。
Calcium binding protein-mediated regulation of voltage-gated calcium channels linked to human diseases.
机构信息
Department of Physiology, Faculty of Medicine, University of Toronto, 3306 MSB, 1 King's College Circle, Toronto, Ontario, Canada.
出版信息
Acta Pharmacol Sin. 2011 Jun;32(6):741-8. doi: 10.1038/aps.2011.64.
Abstract
Calcium ion entry through voltage-gated calcium channels is essential for cellular signalling in a wide variety of cells and multiple physiological processes. Perturbations of voltage-gated calcium channel function can lead to pathophysiological consequences. Calcium binding proteins serve as calcium sensors and regulate the calcium channel properties via feedback mechanisms. This review highlights the current evidences of calcium binding protein-mediated channel regulation in human diseases.
摘要
钙离子通过电压门控钙通道内流对于多种细胞的信号转导以及多种生理过程都是至关重要的。电压门控钙通道功能的紊乱可导致病理生理学后果。钙结合蛋白作为钙传感器，通过反馈机制调节钙通道的性质。本文综述了钙结合蛋白介导的通道调节在人类疾病中的最新证据。
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