手性叔丁基亚磺亚胺与三亚甲基甲烷的环加成反应。

Cycloaddition of chiral tert-butanesulfinimines with trimethylenemethane.

机构信息

School of Chemistry, University of Nottingham, Nottingham, NG7 2RD, UK.

出版信息

Org Lett. 2013 Apr 19;15(8):2030-3. doi: 10.1021/ol400720b. Epub 2013 Apr 4.

Abstract

The cycloaddition of chiral tert-butanesulfinimines with trimethylenemethane is found to give facile access to methylene-pyrrolidines with good yields and diastereoselectivities. The full scope of the cycloaddition is explored, and a range of transformations of the formed methylenepyrrolidines to give a range of functionalized chiral pyrrolidines is presented.

摘要

手性叔丁基亚磺亚胺与三亚甲基甲烷的环加成反应被发现可以很容易地得到高产率和高非对映选择性的亚甲基吡咯烷。本文探索了环加成的全范围，并展示了一系列形成的亚甲基吡咯烷转化为一系列功能化的手性吡咯烷的方法。