Winchester D J, Duda R B, August C Z, Goldschmidt R A, Wruck D M, Rademaker A W, Winchester D P, Merkel D E
Department of Surgery, Northwestern University, Evanston, IL.
Arch Surg. 1990 Jul;125(7):886-9. doi: 10.1001/archsurg.1990.01410190084013.
DNA flow cytometric analysis and conventional clinical factors were compared with disease outcome in 257 patients with node-negative infiltrating ductal carcinoma who had been treated between 1976 and 1983. Median follow-up was 80 months; none of the patients received adjuvant therapy. The relative prognostic importance of clinical variables, ploidy, and S-phase fraction was analyzed by Cox multivariate analysis. Ploidy was analyzable for 198 tumors and did not predict survival. Nuclear grade predicted disease-free survival for all patients. For 71 patients with diploid tumors, only high S-phase had a statistically significant association with relapse. For 127 patients with aneuploid tumors, tumor diameter predicted both disease-free survival and cancer death; histologic grade was also significant for predicting disease-free survival. In conclusion, flow cytometric determination of ploidy and S-phase fraction can provide valuable predictive information in node-negative breast cancer in addition to conventional variables.
对1976年至1983年间接受治疗的257例淋巴结阴性浸润性导管癌患者的DNA流式细胞术分析结果与传统临床因素进行了比较，并与疾病转归相关联。中位随访时间为80个月；所有患者均未接受辅助治疗。通过Cox多变量分析评估临床变量、倍体和S期分数的相对预后重要性。对198个肿瘤进行了倍体分析，结果显示其无法预测生存情况。核分级可预测所有患者的无病生存期。对于71例二倍体肿瘤患者，只有高S期与复发具有统计学显著相关性。对于127例非整倍体肿瘤患者，肿瘤直径可预测无病生存期和癌症死亡；组织学分级对预测无病生存期也具有显著意义。总之，除传统变量外，通过流式细胞术测定倍体和S期分数可为淋巴结阴性乳腺癌提供有价值的预测信息。
