Department of Hand Surgery, Skåne University Hospital, Malmö, Sweden.
Department of Translational Medicine, Lund University, Lund, Sweden.
BMC Musculoskelet Disord. 2024 Nov 22;25(1):944. doi: 10.1186/s12891-024-08073-x.
To determine whether obesity and markers of lipid metabolism are associated with radiological hand osteoarthritis (OA) in the Halland County Osteoarthritis (HALLOA) cohort.
In this cross-sectional study, we included 231 participants aged 30-65 from the HALLOA cohort, which began in 2017 and is ongoing. Hand OA was defined as ≥ 2 joint groups (distal interphalangeal, proximal interphalangeal, and carpometacarpal I) with Kellgren-Lawrence grade ≥ 2. The severity of hand OA was classified in terms of the number of affected joint groups (moderate hand OA 2-4 joint groups, severe hand OA 5-6 joint groups). Metabolic profile, including body mass index (BMI), bioimpedance, waist circumference, blood pressure, serum leptin, total cholesterol, low-density lipoprotein (LDL) cholesterol, high-density lipoprotein (HDL) cholesterol, and triglycerides, were obtained. Multicollinearity was assessed with Pearson's correlation and associations with logistic regression analyses adjusting for age, HDL-cholesterol, and central obesity.
Two-thirds of the participants were women, and 91 (39%) had hand OA. We found a relationship between LDL-cholesterol and prevalent hand OA in women with an odds ratio of 1.7 (95% CI 1.1-2.6) and an association between LDL-cholesterol and severity of hand OA in women; odds ratio for no hand OA vs. moderate hand OA was 1.6 (95% CI 1.0-2.4) and for no hand OA vs. severe hand OA 2.5 (95% CI 1.2-4.9). There were no significant relationships between hand OA and obesity or serum leptin levels.
Circulating LDL-cholesterol levels were associated with the prevalence and severity of hand OA in women but not men.
ClinicalTrials. Gov (NCT04928170), Date of registration: 2017-12-20.
为了确定肥胖和脂质代谢标志物是否与 Halland 县骨关节炎（HALLOA）队列中的影像学手部骨关节炎（OA）相关。
在这项横断面研究中，我们纳入了 2017 年开始并持续进行的 HALLOA 队列中的 231 名 30-65 岁的参与者。手部 OA 的定义为≥2 个关节群（远侧指间、近侧指间和掌指 I）的 Kellgren-Lawrence 分级≥2。手部 OA 的严重程度根据受累关节群的数量分类（中度手部 OA 2-4 个关节群，重度手部 OA 5-6 个关节群）。代谢特征，包括体重指数（BMI）、生物阻抗、腰围、血压、血清瘦素、总胆固醇、低密度脂蛋白（LDL）胆固醇、高密度脂蛋白（HDL）胆固醇和甘油三酯，均被获得。采用 Pearson 相关性评估多共线性，并采用 logistic 回归分析调整年龄、HDL-胆固醇和中心性肥胖进行相关性分析。
三分之二的参与者为女性，91 人（39%）患有手部 OA。我们发现 LDL-胆固醇与女性手部 OA 的患病率相关，OR 值为 1.7（95%CI 1.1-2.6），且 LDL-胆固醇与女性手部 OA 的严重程度相关；与无手部 OA 相比，中度手部 OA 的 OR 值为 1.6（95%CI 1.0-2.4），与重度手部 OA 的 OR 值为 2.5（95%CI 1.2-4.9）。手部 OA 与肥胖或血清瘦素水平之间无显著关系。
循环 LDL-胆固醇水平与女性手部 OA 的患病率和严重程度相关，但与男性无关。
ClinicalTrials.gov（NCT04928170），注册日期：2017 年 12 月 20 日。
