Melanoma cell-secreted soluble factor that stimulates ubiquitination and degradation of the interferon alpha receptor and attenuates its signaling.
作者信息
HuangFu Wei-Chun, Qian Juan, Liu Chengbao, Rui Hallgeir, Fuchs Serge Y
出版信息
Pigment Cell Melanoma Res. 2010 Dec;23(6):838-40. doi: 10.1111/j.1755-148x.2010.00770.x.
Abstract
摘要
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Melanoma cell-secreted soluble factor that stimulates ubiquitination and degradation of the interferon alpha receptor and attenuates its signaling.黑色素瘤细胞分泌的可溶性因子，可刺激干扰素α受体的泛素化和降解，并减弱其信号传导。
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Interferon alpha adjuvant therapy in patients with high-risk melanoma: a systematic review and meta-analysis.干扰素 α 辅助治疗高危黑色素瘤患者：系统评价和荟萃分析。
J Natl Cancer Inst. 2010 Apr 7;102(7):493-501. doi: 10.1093/jnci/djq009. Epub 2010 Feb 23.
2
Inducible priming phosphorylation promotes ligand-independent degradation of the IFNAR1 chain of type I interferon receptor.可诱导的启动磷酸化促进 I 型干扰素受体 IFNAR1 链的配体非依赖性降解。
J Biol Chem. 2010 Jan 22;285(4):2318-25. doi: 10.1074/jbc.M109.071498. Epub 2009 Nov 30.
3
Adjuvant therapy of melanoma with interferon: lessons of the past decade.黑色素瘤的干扰素辅助治疗：过去十年的经验教训。
J Transl Med. 2008 Oct 27;6:62. doi: 10.1186/1479-5876-6-62.
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Activated stat-3 in melanoma.黑色素瘤中激活的信号转导和转录激活因子3
Cancer Control. 2008 Jul;15(3):196-201. doi: 10.1177/107327480801500302.
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Raf inhibitor stabilizes receptor for the type I interferon but inhibits its anti-proliferative effects in human malignant melanoma cells.Raf抑制剂可稳定I型干扰素受体，但在人恶性黑色素瘤细胞中抑制其抗增殖作用。
Cancer Biol Ther. 2007 Sep;6(9):1437-41. doi: 10.4161/cbt.6.9.4569. Epub 2007 Jun 13.
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Negative regulation of type I interferon signaling: facts and mechanisms.I型干扰素信号通路的负调控：事实与机制
Cell Mol Biol (Noisy-le-grand). 2006 May 15;52(1):77-87.
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Mechanisms of type-I- and type-II-interferon-mediated signalling.I型和II型干扰素介导的信号传导机制。
Nat Rev Immunol. 2005 May;5(5):375-86. doi: 10.1038/nri1604.
8
Phosphorylation and specific ubiquitin acceptor sites are required for ubiquitination and degradation of the IFNAR1 subunit of type I interferon receptor.I型干扰素受体的IFNAR1亚基的泛素化和降解需要磷酸化和特定的泛素受体位点。
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9
SCF(HOS) ubiquitin ligase mediates the ligand-induced down-regulation of the interferon-alpha receptor.干细胞因子（HOS）泛素连接酶介导配体诱导的α干扰素受体下调。
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10
Induction of homologue of Slimb ubiquitin ligase receptor by mitogen signaling.
J Biol Chem. 2002 Sep 27;277(39):36624-30. doi: 10.1074/jbc.M204524200. Epub 2002 Jul 31.
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