阿片受体激动剂和拮抗剂对小鼠应激诱导的皮质酮分泌的影响。
The effects of opiate receptor agonists and antagonists on the stress-induced secretion of corticosterone in mice.
作者信息
Gibson A, Ginsburg M, Hall M, Hart S L
出版信息
Br J Pharmacol. 1979 Jan;65(1):139-46. doi: 10.1111/j.1476-5381.1979.tb17342.x.
Abstract
1 Intraperitoneal administration of normorphine, morphine or naloxone or exposure to ether vapour for 1 min, elevated plasma corticosteroid concentrations in mice. 2 Injection of saline or exposure to ether vapour rendered mice less sensitive to a subsequent exposure to ether vapour 15 min later. 3 Treatment with normorphine (50 mg/kg) potentiated the corticosteroid response to ether stress whilst pentazocine (20 mg/kg), naltrexone (10 mg/kg), morphine (24 mg/kg), levorphanol (20 mg/kg) and naloxone (50 mg/kg) prevented the stress-induced elevation of plasma corticosteroids. 4 Both naloxone and morphine inhibited the potentiation by normorphine of the response to ether, the dose of naloxone required being higher than that for inhibition of normorphine analgesia. 5 It is concluded that endogenous opioid peptides may be involved in the control of the response to ether stress in mice.
摘要
- 腹腔注射去甲吗啡、吗啡或纳洛酮，或让小鼠暴露于乙醚蒸气1分钟，均可提高小鼠血浆皮质类固醇浓度。2. 注射生理盐水或暴露于乙醚蒸气会使小鼠对15分钟后再次暴露于乙醚蒸气的敏感性降低。3. 用去甲吗啡（50毫克/千克）处理可增强皮质类固醇对乙醚应激的反应，而喷他佐辛（20毫克/千克）、纳曲酮（10毫克/千克）、吗啡（24毫克/千克）、左啡诺（20毫克/千克）和纳洛酮（50毫克/千克）可防止应激诱导的血浆皮质类固醇升高。4. 纳洛酮和吗啡均抑制去甲吗啡对乙醚反应的增强作用，所需纳洛酮剂量高于抑制去甲吗啡镇痛所需剂量。5. 得出的结论是，内源性阿片肽可能参与了小鼠对乙醚应激反应的控制。
相似文献
1
The effects of opiate receptor agonists and antagonists on the stress-induced secretion of corticosterone in mice.阿片受体激动剂和拮抗剂对小鼠应激诱导的皮质酮分泌的影响。
Br J Pharmacol. 1979 Jan;65(1):139-46. doi: 10.1111/j.1476-5381.1979.tb17342.x.
2
Differences in the effects of mu- and delta-opioid receptor antagonists upon plasma corticosterone levels in stressed mice.μ-阿片受体拮抗剂和δ-阿片受体拮抗剂对应激小鼠血浆皮质酮水平影响的差异。
Eur J Pharmacol. 1984 May 18;101(1-2):153-6. doi: 10.1016/0014-2999(84)90042-6.
3
ACTH and corticosterone response to naloxone and morphine in normal, hypophysectomized and dexamethasone-treated rats.正常、垂体切除及地塞米松处理大鼠对纳洛酮和吗啡的促肾上腺皮质激素及皮质酮反应
Life Sci. 1982 Jul 26;31(4):307-14. doi: 10.1016/0024-3205(82)90407-6.
4
Plasma corticosterone changes in response to central or peripheral administration of kappa and sigma opiate agonists.血浆皮质酮对κ和σ阿片受体激动剂中枢或外周给药的反应变化。
J Pharmacol Exp Ther. 1985 Jun;233(3):863-9.
5
A mechanism of action for morphine-induced immunosuppression: corticosterone mediates morphine-induced suppression of natural killer cell activity.吗啡诱导免疫抑制的作用机制：皮质酮介导吗啡诱导的自然杀伤细胞活性抑制。
J Pharmacol Exp Ther. 1994 Sep;270(3):1127-33.
6
[Long-term enhancement of morphine hypalgesia as a result of periodic blockade of opiate receptors using naloxone].[使用纳洛酮对阿片受体进行周期性阻断导致吗啡镇痛作用的长期增强]
Biull Eksp Biol Med. 1987 Dec;104(12):692-5.
7
Enhancement of naloxone-induced analgesia by pretreatment with morphine.吗啡预处理增强纳洛酮诱导的镇痛作用。
Pharmacol Biochem Behav. 1989 Oct;34(2):425-7. doi: 10.1016/0091-3057(89)90337-7.
8
Serum prolactin response to ether stress in diabetic rats: opiate system contribution.糖尿病大鼠血清催乳素对乙醚应激的反应：阿片系统的作用
Proc Soc Exp Biol Med. 1994 Mar;205(3):248-52. doi: 10.3181/00379727-205-43704.
9
Effects of naloxone on hypothalamo-pituitary-adrenocortical activity in the rat.纳洛酮对大鼠下丘脑 - 垂体 - 肾上腺皮质活动的影响。
Neuroendocrinology. 1986;42(5):421-6. doi: 10.1159/000124481.
10
Naloxone rapidly evokes endogenous kappa opioid receptor-mediated hyperalgesia in naïve mice pretreated briefly with GM1 ganglioside or in chronic morphine-dependent mice.纳洛酮能在预先短暂给予GM1神经节苷脂的未接触过药物的小鼠或慢性吗啡依赖小鼠中迅速诱发内源性κ阿片受体介导的痛觉过敏。
Brain Res. 2007 Sep 5;1167:31-41. doi: 10.1016/j.brainres.2007.06.058. Epub 2007 Jul 14.
引用本文的文献
1
Social stress and escalated drug self-administration in mice I. Alcohol and corticosterone.小鼠的社会压力与药物自我给药行为升级 I. 酒精与皮质酮
Psychopharmacology (Berl). 2015 Mar;232(6):991-1001. doi: 10.1007/s00213-014-3733-9. Epub 2014 Sep 23.
2
Effects of endomorphin-1 on open-field behavior and on the hypothalamic-pituitary-adrenal system.内吗啡肽-1对旷场行为及下丘脑-垂体-肾上腺系统的影响。
Endocrine. 2001 Mar;14(2):221-4. doi: 10.1385/ENDO:14:2:221.
3
Effects of adrenalectomy and hypophysectomy on enkephalin content of the rat hypothalamus.肾上腺切除术和垂体切除术对大鼠下丘脑脑啡肽含量的影响。
Br J Pharmacol. 1980 Dec;70(4):561-9. doi: 10.1111/j.1476-5381.1980.tb09775.x.
4
Leucine-enkephalin and methionine-enkephalin produce opposing effects on plasma corticosterone levels in ether-stressed mice.亮氨酸脑啡肽和甲硫氨酸脑啡肽对乙醚应激小鼠的血浆皮质酮水平产生相反的作用。
Br J Pharmacol. 1980 Dec;70(4):509-11. doi: 10.1111/j.1476-5381.1980.tb09767.x.
5
Developmental responses to opioids reveals a lack of effect on stress-induced corticosterone levels in neonatal rats.对阿片类药物的发育反应表明，其对新生大鼠应激诱导的皮质酮水平没有影响。
Br J Pharmacol. 1987 May;91(1):119-25. doi: 10.1111/j.1476-5381.1987.tb08990.x.
6
Naltrexone. A review of its pharmacodynamic and pharmacokinetic properties and therapeutic efficacy in the management of opioid dependence.纳曲酮。对其药效学和药代动力学特性以及在阿片类药物依赖管理中的治疗效果的综述。
Drugs. 1988 Mar;35(3):192-213. doi: 10.2165/00003495-198835030-00002.
7
Effect of carrageenan-induced acute inflammation on corticosterone levels in mice.角叉菜胶诱导的急性炎症对小鼠皮质酮水平的影响。
Agents Actions. 1990 Mar;29(3-4):196-200. doi: 10.1007/BF01966447.
8
Differential effects of naloxone on neuroendocrine responses to fear-related emotional stress.纳洛酮对与恐惧相关的情绪应激的神经内分泌反应的不同影响。
Exp Brain Res. 1990;81(1):53-8. doi: 10.1007/BF00230100.
9
Changes in corticosterone levels under different degrees of acute inflammation in mice.小鼠不同程度急性炎症下皮质酮水平的变化
Agents Actions. 1992 May;36(1-2):93-8. doi: 10.1007/BF01991235.
10
Appearance of ATP in the coronary sinus effluent from isolated working rat heart in response to hypoxia [proceedings].缺氧时分离的正常工作大鼠心脏冠状窦流出液中ATP的出现[会议论文集]
J Physiol. 1979 Oct;295(Suppl):50P-51P.
本文引用的文献
1
The role of the hypothalamus in pituitary-adrenal activation and antidiuresis by morphine.下丘脑在吗啡激活垂体-肾上腺及抗利尿作用中的作用。
J Pharmacol Exp Ther. 1959 Feb;125(2):111-5.
2
The estimation of small amounts of corticosterone in rat plasma.大鼠血浆中少量皮质酮的测定。
J Biol Chem. 1958 Apr;231(2):695-701.
3
Immunohistochemical studies using antibodies to leucine-enkephalin: initial observations on the nervous system of the rat.使用抗亮氨酸脑啡肽抗体的免疫组织化学研究：对大鼠神经系统的初步观察。
Neuroscience. 1976 Aug;1(4):349-51. doi: 10.1016/0306-4522(76)90063-4.
4
Pituitary-adrenal activation following intrahypothalamic microinjection of morphine.下丘脑内微量注射吗啡后垂体-肾上腺的激活
Neuroendocrinology. 1969;4(6):326-32. doi: 10.1159/000121765.
5
Characteristics of fast feedback control of corticotrophin release by corticosteroids.皮质类固醇对促肾上腺皮质激素释放的快速反馈控制的特征
J Endocrinol. 1972 Dec;55(3):489-97. doi: 10.1677/joe.0.0550489.
6
Dynamic asymmetries in the corticosteroid feedback path and distribution-metabolism-binding elements of the adrenocortical system.皮质类固醇反馈途径以及肾上腺皮质系统的分布-代谢-结合元件中的动态不对称性。
Ann N Y Acad Sci. 1969 Apr 21;156(2):696-721. doi: 10.1111/j.1749-6632.1969.tb14008.x.
7
Regional distribution of opiate receptor binding in monkey and human brain.猴脑和人脑阿片受体结合的区域分布。
Nature. 1973 Oct 26;245(5426):447-50. doi: 10.1038/245447a0.
8
Analgesia induced in vivo by central administration of enkephalin in rat.大鼠体内通过脑室内注射脑啡肽诱导产生的镇痛作用。
Nature. 1976 Apr 15;260(5552):625-6. doi: 10.1038/260625a0.
9
Identification of two related pentapeptides from the brain with potent opiate agonist activity.从大脑中鉴定出两种具有强效阿片激动剂活性的相关五肽。
Nature. 1975 Dec 18;258(5536):577-80. doi: 10.1038/258577a0.
10
A peptide-like substance from pituitary that acts like morphine. 2. Purification and properties.1. 一种来自垂体的、作用类似吗啡的肽样物质。2. 纯化及特性。
Life Sci. 1975 Jun 15;16(12):1777-82. doi: 10.1016/0024-3205(75)90272-6.
Zotero 插件