亮氨酸脑啡肽和甲硫氨酸脑啡肽对乙醚应激小鼠的血浆皮质酮水平产生相反的作用。
Leucine-enkephalin and methionine-enkephalin produce opposing effects on plasma corticosterone levels in ether-stressed mice.
作者信息
Gibson A, Hart S L, Shabib A
出版信息
Br J Pharmacol. 1980 Dec;70(4):509-11. doi: 10.1111/j.1476-5381.1980.tb09767.x.
Abstract
The inhibitory effects of intracerebroventricular administration of saline on the plasma corticosterone response to ether stress in mice was reduced by Met-enkephalin and enhanced by Leu-enkephalin. When administered simultaneously the effects of the two peptides opposed each other. Met and Leu-enkephalin may subserve different physiological functions in the response of the hypothalamus-pituitary-adrenal system to stress.
摘要
脑室内注射生理盐水对小鼠血浆皮质酮对应激反应的抑制作用，在甲硫氨酸脑啡肽作用下减弱，而在亮氨酸脑啡肽作用下增强。当同时给予这两种肽时，它们的作用相互拮抗。甲硫氨酸脑啡肽和亮氨酸脑啡肽在应激时下丘脑-垂体-肾上腺系统反应中可能发挥不同的生理功能。
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Leucine-enkephalin and methionine-enkephalin produce opposing effects on plasma corticosterone levels in ether-stressed mice.亮氨酸脑啡肽和甲硫氨酸脑啡肽对乙醚应激小鼠的血浆皮质酮水平产生相反的作用。
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本文引用的文献
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The estimation of small amounts of corticosterone in rat plasma.大鼠血浆中少量皮质酮的测定。
J Biol Chem. 1958 Apr;231(2):695-701.
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Pharmacological effects produced by intracerebral injection of drugs in the conscious mouse.清醒小鼠脑内注射药物所产生的药理效应。
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Foot shock induced stress decreases leu5-enkephalin immunoreactivity in rat hypothalamus.足部电击诱导的应激会降低大鼠下丘脑亮氨酸脑啡肽免疫反应性。
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The effect of intracerebroventricular administration of methionine-enkephalin on the stress-induced secretion of corticosterone in mice.脑室内注射甲硫氨酸脑啡肽对小鼠应激诱导的皮质酮分泌的影响。
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Met- and Leu-enkephalin immunoreactivity in separate neurones.甲硫氨酸脑啡肽和亮氨酸脑啡肽在不同神经元中的免疫反应性。
Nature. 1979 Nov 22;282(5737):407-10. doi: 10.1038/282407a0.
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The effects of opiate receptor agonists and antagonists on the stress-induced secretion of corticosterone in mice.阿片受体激动剂和拮抗剂对小鼠应激诱导的皮质酮分泌的影响。
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