Sin Y M, Chio S L
Department of Zoology, National University of Singapore.
Agents Actions. 1990 Mar;29(3-4):196-200. doi: 10.1007/BF01966447.
Changes in corticosterone levels in plasma and inflammatory exudate were studied in the 6-day-old air pouch of mice. The pouch inflammation in the test group was induced by the injection of carrageenan prepared in physiological saline while the control received only the physiological saline. The results show that exudate and plasma of both groups showed a rapid rise in corticosterone as measured after 30 min and this early rise was probably due to the resulting effect of the ether used during the injection of irritant or vehicle. In contrast, corticosterone levels in the inflammatory exudate of the test group increased with time, reaching a peak at 24 hours after the carrageenan injection. The increased corticosterone levels in the inflammatory exudate appeared to be closely correlated with the increased exudate cell accumulation. This suggests that the increased accumulation of exudate corticosterone in the pouch might play an important role at the inflammatory site by modulating intensity of the inflammatory reactivity caused by the irritant.
对6日龄小鼠气袋中的血浆和炎性渗出物中皮质酮水平的变化进行了研究。试验组的气袋炎症通过注射用生理盐水配制的角叉菜胶诱导，而对照组仅接受生理盐水。结果显示，两组的渗出物和血浆在30分钟后测量时皮质酮均迅速升高，这种早期升高可能是由于注射刺激物或赋形剂期间使用的乙醚的作用。相比之下，试验组炎性渗出物中的皮质酮水平随时间增加，在注射角叉菜胶后24小时达到峰值。炎性渗出物中皮质酮水平的升高似乎与渗出细胞积累的增加密切相关。这表明气袋中渗出性皮质酮积累的增加可能通过调节刺激物引起的炎症反应强度在炎症部位发挥重要作用。
