Department of Obstetrics and Gynecology, University of Naples "Federico II", Naples, Italy.
Fertil Steril. 2011 Jul;96(1):214-9. doi: 10.1016/j.fertnstert.2011.05.004. Epub 2011 Jun 8.
To evaluate the impact of hormone replacement therapy and oral contraceptives containing different progestogens on adiponectin and leptin serum levels.
Prospective, longitudinal, semi-randomized study.
General gynecology clinic of a university hospital.
PATIENT(S): Forty-five healthy postmenopausal and 45 healthy premenopausal women.
INTERVENTION(S): Thirty postmenopausal women were randomized to receive either drospirenone (DRSP) 2 mg + E(2) 1 mg (n = 15) or norethisterone acetate (NETA) 0.5 mg + E(2) 1 mg (n = 15). Thirty premenopausal women were randomized to receive either ethinilestradiol (EE) 0.020 mg + DRSP 3 mg (n = 15) or EE 0.020 mg + desogestrel 0.15 mg (n = 15). Furthermore, 15 postmenopausal and 15 premenopausal untreated women served as controls.
MAIN OUTCOME MEASURE(S): Adiponectin and leptin serum levels before and after 6 months of hormonal therapy.
RESULT(S): No significant differences in leptin levels were detected in any group after 6 months. Adiponectin levels were significantly reduced in the NETA + E(2) group and increased in the EE + DRSP group, while remaining unmodified in all other groups.
CONCLUSION(S): Hormone replacement therapy with NETA, but not with DRSP, decreases serum adiponectin levels. Oral contraceptives containing DRSP increase serum adiponectin levels.
评估不同孕激素的激素替代疗法和口服避孕药对脂联素和瘦素血清水平的影响。
前瞻性、纵向、半随机研究。
一所大学医院的普通妇科诊所。
45 名健康绝经后和 45 名健康绝经前妇女。
30 名绝经后妇女被随机分为屈螺酮（DRSP）2 毫克+E2 1 毫克（n = 15）或醋酸炔诺酮（NETA）0.5 毫克+E2 1 毫克（n = 15）。30 名绝经前妇女被随机分为屈螺酮（DRSP）3 毫克+乙炔雌二醇（EE）0.020 毫克（n = 15）或去氧孕烯 0.15 毫克+EE 0.020 毫克（n = 15）。此外，15 名未经治疗的绝经后和 15 名未经治疗的绝经前妇女作为对照组。
激素治疗前和治疗后 6 个月的脂联素和瘦素血清水平。
治疗 6 个月后，任何组的瘦素水平均无显著差异。NETA+E2 组脂联素水平显著降低，EE+DRSP 组脂联素水平升高，而其他组无变化。
NETA 而不是 DRSP 的激素替代疗法可降低血清脂联素水平。含有 DRSP 的口服避孕药可增加血清脂联素水平。
