Engelman A, Rosenberg N
Department of Molecular Biology and Microbiology, Tufts University School of Medicine, Boston, Massachusetts 02111.
Mol Cell Biol. 1990 Aug;10(8):4365-9. doi: 10.1128/mcb.10.8.4365-4369.1990.
Lymphoid cells transformed by temperature-sensitive Abelson virus die at the nonpermissive temperature. This property was exploited to show that bcr/abl and v-src but not myc and ras can replace the transforming signal of v-abl, a result suggesting that the former but not the latter oncogenes transform lymphoid cells via a similar pathway.
由温度敏感型阿贝尔森病毒转化的淋巴细胞在非允许温度下会死亡。利用这一特性表明,bcr/abl和v-src而非myc和ras能够取代v-abl的转化信号,这一结果表明,前一组癌基因而非后一组癌基因通过相似途径转化淋巴细胞。