阿贝尔森病毒消除淋巴细胞系对白介素-3的依赖性

Mathey-Prevot B, Nabel G, Palacios R, Baltimore D

Mol Cell Biol. 1986 Nov;6(11):4133-5. doi: 10.1128/mcb.6.11.4133-4135.1986.

Among several tyrosine-protein kinases, only v-abl could abrogate interleukin 3 dependence of a lymphoblastoid cell line; v-src and v-fps proteins gave partial or no interleukin 3 independence, respectively. Lymphokine independence was achieved via a nonautocrine mechanism. Direct involvement of c-myc in this process was not evident.

在几种酪氨酸蛋白激酶中，只有v-abl能消除淋巴母细胞系对白细胞介素3的依赖性；v-src和v-fps蛋白分别使细胞部分依赖或完全依赖白细胞介素3。细胞因子非依赖性是通过非自分泌机制实现的。c-myc在此过程中的直接作用并不明显。