• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

阿贝尔森病毒消除淋巴细胞系对白介素-3的依赖性

Abelson virus abrogation of interleukin-3 dependence in a lymphoid cell line.

作者信息

Mathey-Prevot B, Nabel G, Palacios R, Baltimore D

出版信息

Mol Cell Biol. 1986 Nov;6(11):4133-5. doi: 10.1128/mcb.6.11.4133-4135.1986.

DOI:10.1128/mcb.6.11.4133-4135.1986
PMID:3025637
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC367185/
Abstract

Among several tyrosine-protein kinases, only v-abl could abrogate interleukin 3 dependence of a lymphoblastoid cell line; v-src and v-fps proteins gave partial or no interleukin 3 independence, respectively. Lymphokine independence was achieved via a nonautocrine mechanism. Direct involvement of c-myc in this process was not evident.

摘要

在几种酪氨酸蛋白激酶中，只有v-abl能消除淋巴母细胞系对白细胞介素3的依赖性；v-src和v-fps蛋白分别使细胞部分依赖或完全依赖白细胞介素3。细胞因子非依赖性是通过非自分泌机制实现的。c-myc在此过程中的直接作用并不明显。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5118/367185/f6fe5054b04d/molcellb00095-0579-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5118/367185/bb756dfc9617/molcellb00095-0578-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5118/367185/73dc942a0fa1/molcellb00095-0578-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5118/367185/f6fe5054b04d/molcellb00095-0579-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5118/367185/bb756dfc9617/molcellb00095-0578-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5118/367185/73dc942a0fa1/molcellb00095-0578-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5118/367185/f6fe5054b04d/molcellb00095-0579-a.jpg

相似文献

1
Abelson virus abrogation of interleukin-3 dependence in a lymphoid cell line.阿贝尔森病毒消除淋巴细胞系对白介素-3的依赖性
Mol Cell Biol. 1986 Nov;6(11):4133-5. doi: 10.1128/mcb.6.11.4133-4135.1986.
2
Structure and function of the Abelson murine leukemia virus transforming gene.阿贝尔逊鼠白血病病毒转化基因的结构与功能
Prog Clin Biol Res. 1983;119:57-63.
3
Tyrosine kinase oncogenes abrogate interleukin-3 dependence of murine myeloid cells through signaling pathways involving c-myc: conditional regulation of c-myc transcription by temperature-sensitive v-abl.酪氨酸激酶癌基因通过涉及c-myc的信号通路消除小鼠髓样细胞对白介素-3的依赖性：温度敏感型v-abl对c-myc转录的条件性调控。
Mol Cell Biol. 1989 Dec;9(12):5685-95. doi: 10.1128/mcb.9.12.5685-5695.1989.
4
Abelson virus: current status of a viral oncogene.
Proc Soc Exp Biol Med. 1988 Jul;188(3):235-42. doi: 10.3181/00379727-188-42732.
5
bcr/abl and src but not myc and ras replace v-abl in lymphoid transformation.bcr/abl和src而非myc和ras在淋巴样转化中取代了v-abl。
Mol Cell Biol. 1990 Aug;10(8):4365-9. doi: 10.1128/mcb.10.8.4365-4369.1990.
6
Introduction of v-abl oncogene induces monocytic differentiation of an IL-3-dependent myeloid progenitor cell line.v-abl癌基因的导入诱导了白细胞介素-3依赖的髓系祖细胞系的单核细胞分化。
Oncogene. 1990 Apr;5(4):549-55.
7
The Abelson murine leukemia virus oncogene.阿贝尔森鼠白血病病毒癌基因。
Proc Soc Exp Biol Med. 1985 Sep;179(4):403-12. doi: 10.3181/00379727-179-42115.
8
Conservation of function of Drosophila melanogaster abl and murine v-abl proteins in transformation of mammalian cells.黑腹果蝇abl蛋白和鼠类v-abl蛋白在哺乳动物细胞转化中的功能保守性。
J Virol. 1990 May;64(5):2226-35. doi: 10.1128/JVI.64.5.2226-2235.1990.
9
Isolation and characterization of temperature-sensitive mutants of Abelson murine leukaemia virus that exhibit dissociation among morphological transformation, soft agar colony-forming ability and tyrosine kinase activity.阿贝尔逊鼠白血病病毒温度敏感突变体的分离与鉴定，这些突变体在形态转化、软琼脂集落形成能力和酪氨酸激酶活性之间表现出解离。
J Gen Virol. 1989 Sep;70 ( Pt 9):2527-32. doi: 10.1099/0022-1317-70-9-2527.
10
Nucleotide sequence of Abelson murine leukemia virus genome: structural similarity of its transforming gene product to other onc gene products with tyrosine-specific kinase activity.阿贝尔逊鼠白血病病毒基因组的核苷酸序列：其转化基因产物与其他具有酪氨酸特异性激酶活性的癌基因产物的结构相似性。
Proc Natl Acad Sci U S A. 1983 Jun;80(12):3623-7. doi: 10.1073/pnas.80.12.3623.

引用本文的文献

1
Inhibition of fibroblast growth factor receptor 3-dependent lung adenocarcinoma with a human monoclonal antibody.用人源单克隆抗体抑制成纤维细胞生长因子受体3依赖性肺腺癌
Dis Model Mech. 2016 May 1;9(5):563-71. doi: 10.1242/dmm.024760. Epub 2016 Apr 7.
2
Activation of tyrosine kinases by mutation of the gatekeeper threonine.通过守门苏氨酸突变激活酪氨酸激酶。
Nat Struct Mol Biol. 2008 Oct;15(10):1109-18. doi: 10.1038/nsmb.1486. Epub 2008 Sep 14.
3
Direct interaction of Jak1 and v-Abl is required for v-Abl-induced activation of STATs and proliferation.

本文引用的文献

1
Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxicity assays.用于细胞生长和存活的快速比色测定法：应用于增殖和细胞毒性测定。
J Immunol Methods. 1983 Dec 16;65(1-2):55-63. doi: 10.1016/0022-1759(83)90303-4.
2
Construction and applications of a highly transmissible murine retrovirus shuttle vector.一种高传染性小鼠逆转录病毒穿梭载体的构建与应用
Cell. 1984 Jul;37(3):1053-62. doi: 10.1016/0092-8674(84)90440-9.
3
Isolation and characterization of a mouse cDNA clone that expresses mast-cell growth-factor activity in monkey cells.
v-Abl诱导的STATs激活和细胞增殖需要Jak1与v-Abl的直接相互作用。
Mol Cell Biol. 1998 Nov;18(11):6795-804. doi: 10.1128/MCB.18.11.6795.
4
Identification of the cytoplasmic regions of fibroblast growth factor (FGF) receptor 1 which play important roles in induction of neurite outgrowth in PC12 cells by FGF-1.鉴定成纤维细胞生长因子（FGF）受体1的胞质区域，这些区域在FGF-1诱导PC12细胞神经突生长中起重要作用。
Mol Cell Biol. 1998 Jul;18(7):3762-70. doi: 10.1128/MCB.18.7.3762.
5
An array of novel murine spleen focus-forming viruses that activate the erythropoietin receptor.一系列可激活促红细胞生成素受体的新型小鼠脾集落形成病毒。
J Virol. 1998 May;72(5):3742-50. doi: 10.1128/JVI.72.5.3742-3750.1998.
6
Origin and rapid evolution of a novel murine erythroleukemia virus of the spleen focus-forming virus family.脾脏病灶形成病毒家族一种新型鼠类红白血病病毒的起源与快速进化
J Virol. 1998 May;72(5):3602-9. doi: 10.1128/JVI.72.5.3602-3609.1998.
7
Sequence flexibility in the polytropic env gp70-derived region of the membrane glycoprotein (gp55) of Friend spleen focus-forming virus affects its biological activity.弗氏脾脏灶形成病毒膜糖蛋白（gp55）的多嗜性env gp70衍生区域中的序列灵活性影响其生物学活性。
J Virol. 1998 Mar;72(3):2272-9. doi: 10.1128/JVI.72.3.2272-2279.1998.
8
v-Abl activates c-myc transcription through the E2F site.v-Abl 通过 E2F 位点激活 c-myc 转录。
Mol Cell Biol. 1995 Dec;15(12):6535-44. doi: 10.1128/MCB.15.12.6535.
9
A Friend virus mutant that overcomes Fv-2rr host resistance encodes a small glycoprotein that dimerizes, is processed to cell surfaces, and specifically activates erythropoietin receptors.一种克服Fv - 2rr宿主抗性的Friend病毒突变体编码一种小糖蛋白，该糖蛋白会二聚化，被加工到细胞表面，并特异性激活促红细胞生成素受体。
J Virol. 1993 May;67(5):2611-20. doi: 10.1128/JVI.67.5.2611-2620.1993.
10
SH1 domain autophosphorylation of P210 BCR/ABL is required for transformation but not growth factor independence.P210 BCR/ABL的SH1结构域自身磷酸化是细胞转化所必需的，但并非生长因子非依赖性所必需。
Mol Cell Biol. 1993 Mar;13(3):1728-36. doi: 10.1128/mcb.13.3.1728-1736.1993.
一个在猴细胞中表达肥大细胞生长因子活性的小鼠cDNA克隆的分离与鉴定。
Proc Natl Acad Sci U S A. 1984 Feb;81(4):1070-4. doi: 10.1073/pnas.81.4.1070.
4
The mouse c-abl locus: molecular cloning and characterization.小鼠c-abl基因座：分子克隆与特性分析。
Cell. 1984 Feb;36(2):349-56. doi: 10.1016/0092-8674(84)90228-9.
5
Abelson murine leukaemia virus protein is phosphorylated in vitro to form phosphotyrosine.阿贝尔逊鼠白血病病毒蛋白在体外被磷酸化形成磷酸酪氨酸。
Nature. 1980 Feb 28;283(5750):826-31. doi: 10.1038/283826a0.
6
Molecular basis of heavy-chain class switching and switch region deletion in an Abelson virus-transformed cell line.艾贝尔逊病毒转化细胞系中重链类别转换和转换区缺失的分子基础。
Mol Cell Biol. 1984 Dec;4(12):2905-10. doi: 10.1128/mcb.4.12.2905-2910.1984.
7
Abrogation of IL-3 and IL-2 dependence by recombinant murine retroviruses expressing v-myc oncogenes.
Nature. 1985;317(6036):434-8. doi: 10.1038/317434a0.
8
Il-3-dependent mouse clones that express B-220 surface antigen, contain Ig genes in germ-line configuration, and generate B lymphocytes in vivo.依赖白细胞介素-3的小鼠克隆，表达B-220表面抗原，含有种系构型的免疫球蛋白基因，并在体内产生B淋巴细胞。
Cell. 1985 Jul;41(3):727-34. doi: 10.1016/s0092-8674(85)80053-2.
9
Specific transforming potential of oncogenes encoding protein-tyrosine kinases.编码蛋白酪氨酸激酶的癌基因的特定转化潜能。
EMBO J. 1985 Jul;4(7):1769-74. doi: 10.1002/j.1460-2075.1985.tb03849.x.
10
Neoplastic transformation of mast cells by Abelson-MuLV: abrogation of IL-3 dependence by a nonautocrine mechanism.阿贝尔森鼠白血病病毒诱导肥大细胞的肿瘤转化：通过非自分泌机制消除对白细胞介素-3的依赖性。
Cell. 1985 Jul;41(3):685-93. doi: 10.1016/s0092-8674(85)80049-0.