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巨细胞病毒增强子：转基因小鼠中的一种全活性控制元件。

The cytomegalovirus enhancer: a pan-active control element in transgenic mice.

作者信息

Schmidt E V, Christoph G, Zeller R, Leder P

机构信息

Department of Genetics, Harvard Medical School, Howard Hughes Medical Institute, Boston, Massachusetts 02115.

出版信息

Mol Cell Biol. 1990 Aug;10(8):4406-11. doi: 10.1128/mcb.10.8.4406-4411.1990.

DOI:10.1128/mcb.10.8.4406-4411.1990
PMID:2164640
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC361001/
Abstract

In an effort to identify widely active positive regulatory elements, we have examined the action of the cytomegalovirus enhancer-promoter in transgenic mice. These elements activated expression in 24 of 28 tissues tested. The greatest expression was observed in the heart, kidney, brain, and testis. Maximum expression further localized to specific cells within the heart and kidney.

摘要

为了鉴定具有广泛活性的正向调控元件，我们研究了巨细胞病毒增强子-启动子在转基因小鼠中的作用。这些元件在28个测试组织中的24个中激活了表达。在心脏、肾脏、大脑和睾丸中观察到最强的表达。最大表达进一步定位于心脏和肾脏内的特定细胞。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8896/361001/631abeaefa36/molcellb00044-0564-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8896/361001/c56c058c216c/molcellb00044-0562-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8896/361001/631abeaefa36/molcellb00044-0564-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8896/361001/c56c058c216c/molcellb00044-0562-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8896/361001/631abeaefa36/molcellb00044-0564-a.jpg

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