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俄罗斯替代酒精中邻苯二甲酸二乙酯和聚六亚甲基胍的测定。

Determination of diethyl phthalate and polyhexamethylene guanidine in surrogate alcohol from Russia.

作者信息

Monakhova Yulia B, Kuballa Thomas, Leitz Jenny, Lachenmeier Dirk W

机构信息

Chemisches und Veterinäruntersuchungsamt (CVUA) Karlsruhe, Weissenburger Stra β e 3, 76187 Karlsruhe, Germany.

出版信息

Int J Anal Chem. 2011;2011:704795. doi: 10.1155/2011/704795. Epub 2011 May 17.

DOI:10.1155/2011/704795
PMID:21647285
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3103849/
Abstract

Analytical methods based on spectroscopic techniques were developed and validated for the determination of diethyl phthalate (DEP) and polyhexamethylene guanidine (PHMG), which may occur in unrecorded alcohol. Analysis for PHMG was based on UV-VIS spectrophotometry after derivatization with Eosin Y and (1)H NMR spectroscopy of the DMSO extract. Analysis of DEP was performed with direct UV-VIS and (1)H NMR methods. Multivariate curve resolution and spectra computation methods were used to confirm the presence of PHMG and DEP in the investigated beverages. Of 22 analysed alcohol samples, two contained DEP or PHMG. (1)H NMR analysis also revealed the presence of signals of hawthorn extract in three medicinal alcohols used as surrogate alcohol. The simple and cheap UV-VIS methods can be used for rapid screening of surrogate alcohol samples for impurities, while (1)H NMR is recommended for specific confirmatory analysis if required.

摘要

开发并验证了基于光谱技术的分析方法，用于测定邻苯二甲酸二乙酯（DEP）和聚六亚甲基胍（PHMG），这些物质可能存在于未记录的酒精中。对PHMG的分析基于用曙红Y衍生化后的紫外可见分光光度法以及二甲基亚砜提取物的¹H NMR光谱法。采用直接紫外可见和¹H NMR方法对DEP进行分析。运用多元曲线分辨和光谱计算方法来确认所研究饮料中PHMG和DEP的存在。在22个分析的酒精样品中，有两个含有DEP或PHMG。¹H NMR分析还揭示了在用作替代酒精的三种药用酒精中存在山楂提取物的信号。简单且廉价的紫外可见方法可用于快速筛选替代酒精样品中的杂质，而如果需要，¹H NMR推荐用于特定的确证分析。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0132/3103849/0a7b63423d84/IJAC2011-704795.004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0132/3103849/3b90c1515ce5/IJAC2011-704795.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0132/3103849/95c61e8d76f8/IJAC2011-704795.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0132/3103849/c682b3b61187/IJAC2011-704795.003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0132/3103849/0a7b63423d84/IJAC2011-704795.004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0132/3103849/3b90c1515ce5/IJAC2011-704795.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0132/3103849/95c61e8d76f8/IJAC2011-704795.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0132/3103849/c682b3b61187/IJAC2011-704795.003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0132/3103849/0a7b63423d84/IJAC2011-704795.004.jpg

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本文引用的文献

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Compr Rev Food Sci Food Saf. 2010 Jan;9(1):21-43. doi: 10.1111/j.1541-4337.2009.00093.x.
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[Forensic chemical investigation of alcohol-containing liquids contained polyhexamethylene guanidine hydrochloride and diethylphthalate].[含盐酸聚六亚甲基胍和邻苯二甲酸二乙酯的含酒精液体的法医化学调查]
Sud Med Ekspert. 2010 Jul-Aug;53(4):33-7.
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NMR-spectroscopy for nontargeted screening and simultaneous quantification of health-relevant compounds in foods: the example of melamine.
World J Gastroenterol. 2014 Jun 21;20(23):7217-22. doi: 10.3748/wjg.v20.i23.7217.
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Unrecorded alcohol consumption in Russia: toxic denaturants and disinfectants pose additional risks.俄罗斯未记录的酒精消费情况：有毒变性剂和消毒剂带来额外风险。
Interdiscip Toxicol. 2011 Dec;4(4):198-205. doi: 10.2478/v10102-011-0030-x.
NMR 光谱法用于非靶向筛选和同时定量食品中与健康相关的化合物：以三聚氰胺为例。
J Agric Food Chem. 2009 Aug 26;57(16):7194-9. doi: 10.1021/jf902038j.
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Chemometrics-assisted spectrophotometric method for simultaneous determination of vitamins in complex mixtures.化学计量学辅助分光光度法同时测定复杂混合物中的维生素。
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Chemical analysis and risk assessment of diethyl phthalate in alcoholic beverages with special regard to unrecorded alcohol.化学分析及邻苯二甲酸二乙酯在酒精饮料中的风险评估，特别针对未记录酒精含量的情况。
PLoS One. 2009 Dec 2;4(12):e8127. doi: 10.1371/journal.pone.0008127.
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Alcohol Clin Exp Res. 2007 Oct;31(10):1613-24. doi: 10.1111/j.1530-0277.2007.00474.x. Epub 2007 Aug 6.