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pleiotrophin 过表达为帕金森病大鼠的多巴胺能神经元提供营养支持。

Pleiotrophin over-expression provides trophic support to dopaminergic neurons in parkinsonian rats.

机构信息

Laboratorio de Parkinson Experimental, Instituto de Investigaciones Farmacológicas (ININFA-CONICET-UBA), Ciudad Autónoma de Buenos Aires, Argentina.

出版信息

Mol Neurodegener. 2011 Jun 7;6:40. doi: 10.1186/1750-1326-6-40.

DOI:10.1186/1750-1326-6-40
PMID:21649894
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3130680/
Abstract

BACKGROUND

Pleiotrophin is known to promote the survival and differentiation of dopaminergic neurons in vitro and is up-regulated in the substantia nigra of Parkinson's disease patients. To establish whether pleiotrophin has a trophic effect on nigrostriatal dopaminergic neurons in vivo, we injected a recombinant adenovirus expressing pleiotrophin in the substantia nigra of 6-hydroxydopamine lesioned rats.

RESULTS

The viral vector induced pleiotrophin over-expression by astrocytes in the substantia nigra pars compacta, without modifying endogenous neuronal expression. The percentage of tyrosine hydroxylase-immunoreactive cells as well as the area of their projections in the lesioned striatum was higher in pleiotrophin-treated animals than in controls.

CONCLUSIONS

These results indicate that pleiotrophin over-expression partially rescues tyrosine hydroxylase-immunoreactive cell bodies and terminals of dopaminergic neurons undergoing 6-hydroxydopamine-induced degeneration.

摘要

背景

已知外胚层蛋白可促进多巴胺能神经元在体外的存活和分化，并在帕金森病患者的黑质中上调。为了确定外胚层蛋白对体内黑质纹状体多巴胺能神经元是否具有营养作用，我们在 6-羟多巴胺损伤的大鼠黑质中注射了表达外胚层蛋白的重组腺病毒。

结果

病毒载体诱导星形胶质细胞中脑黑质致密部的外胚层蛋白过度表达，而不改变内源性神经元的表达。与对照组相比，外胚层蛋白处理组的酪氨酸羟化酶免疫反应性细胞的百分比以及其在损伤纹状体中的投射面积更高。

结论

这些结果表明，外胚层蛋白过度表达部分挽救了经历 6-羟多巴胺诱导变性的酪氨酸羟化酶免疫反应性神经元细胞体和末梢。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/01ef/3130680/266a42e0cb08/1750-1326-6-40-7.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/01ef/3130680/26fb0f5a0d45/1750-1326-6-40-1.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/01ef/3130680/c1cfedf6fa93/1750-1326-6-40-4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/01ef/3130680/a2052e798b6c/1750-1326-6-40-5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/01ef/3130680/49a8ede8bec5/1750-1326-6-40-6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/01ef/3130680/266a42e0cb08/1750-1326-6-40-7.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/01ef/3130680/26fb0f5a0d45/1750-1326-6-40-1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/01ef/3130680/d4190839a556/1750-1326-6-40-2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/01ef/3130680/4f72efa08a42/1750-1326-6-40-3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/01ef/3130680/c1cfedf6fa93/1750-1326-6-40-4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/01ef/3130680/a2052e798b6c/1750-1326-6-40-5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/01ef/3130680/49a8ede8bec5/1750-1326-6-40-6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/01ef/3130680/266a42e0cb08/1750-1326-6-40-7.jpg

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Neurobiol Dis. 2010 Mar;37(3):630-40. doi: 10.1016/j.nbd.2009.11.018. Epub 2009 Dec 5.
3
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