氢化可的松与人类白细胞的迁移：由单核细胞介导的间接效应。
Hydrocortisone and the migration of human leucocytes: an indirect effect mediated by mononuclear cells.
作者信息
Stevenson R D
出版信息
Clin Exp Immunol. 1973 Jul;14(3):417-26.
Abstract
Culture of human mononuclear leucocytes in the presence of hydrocortisone results in the appearance in the culture medium of a factor which markedly stimulates the migration of human polymorphonuclear leucocytes . This effect is not due directly to hydrocortisone, which has an inhibitory effect on polymorph migration. The steroid–mononuclear cell interaction is dependent on the duration and temperature of the culture, and on the concentration of hydrocortisone. It is therefore suggested that an active biological process is involved which may be relevant to the immunosuppressive action of corticosteroids.
摘要
在氢化可的松存在的情况下培养人单核白细胞，会导致培养基中出现一种能显著刺激人多形核白细胞迁移的因子。这种作用并非直接由氢化可的松引起，因为氢化可的松对多形核白细胞的迁移有抑制作用。类固醇与单核细胞的相互作用取决于培养的持续时间、温度以及氢化可的松的浓度。因此有人提出，这涉及一个活跃的生物学过程，该过程可能与皮质类固醇的免疫抑制作用有关。
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