Freitas A A, Bognacki J
Immunology. 1979 Feb;36(2):247-55.
In this study, the role of cell locomotion in lymphocyte traffic was investigated following the in vivo fate of 51Cr labelled lymph node cells pretreated in vitro with substances known to modify cell motility. The results obtained show that lymphocyte migration is an energy dependent process, as it could be impaired by sodium azide. That it requires the integrity of microfilaments, as it was modified by Cytochalasin B; and that it is altered by isoproterenol, theophylline, prostaglandin E1 and dibutyryl cyclic-AMP. The relevance of these findings to the process of lymphocyte recirculation is discussed.
在本研究中，在用已知可改变细胞运动性的物质体外预处理51Cr标记的淋巴结细胞后，追踪其体内命运，以此研究细胞运动在淋巴细胞迁移中的作用。所获结果表明，淋巴细胞迁移是一个能量依赖过程，因为叠氮化钠可损害该过程。它需要微丝的完整性，因为细胞松弛素B可改变该过程；并且异丙肾上腺素、茶碱、前列腺素E1和二丁酰环磷腺苷可改变该过程。本文讨论了这些发现与淋巴细胞再循环过程的相关性。
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