Aoki K, Miyagawa K
Second Department of Internal Medicine, Nagoya City University Medical School, Japan.
J Hypertens. 1990 Jun;8(6):579-83. doi: 10.1097/00004872-199006000-00012.
The effects of intravenous calcium infusion on blood pressure (BP) and total peripheral vascular resistance (TPR) were investigated in seven normotensives at rates of 3.75, 7.5 and 15.0 mg/kg per h for 1 h. The infusions increased serum calcium levels, with significant elevations of BP and TPR, but had no effect on cardiac output, indicating that the TPR elevation induced the BP rise. The increase in serum calcium was correlated with elevations of systolic, diastolic and mean BP and TPR (r = 0.74, 0.78, 0.77 and 0.82, respectively; P less than 0.001); greater increases in serum calcium resulted in greater elevations of TPR and BP. The serum calcium increase was also associated with reductions in plasma parathyroid hormone and renin activity, and an increase in plasma aldosterone, which might have contributed to the rise in BP. Our results suggest that an increased serum calcium level led to calcium influx into arterial smooth muscle, which increases cytosolic calcium, induces muscle contraction, and thereby produces arterial vasoconstriction, leading to elevations of TPR and BP.
对7名血压正常者以每小时3.75、7.5和15.0毫克/千克的速率静脉输注钙1小时，研究其对血压（BP）和总外周血管阻力（TPR）的影响。输注使血清钙水平升高，血压和总外周血管阻力显著升高，但对心输出量无影响，表明总外周血管阻力升高导致血压升高。血清钙升高与收缩压、舒张压和平均血压以及总外周血管阻力升高相关（r分别为0.74、0.78、0.77和0.82；P小于0.001）；血清钙升高幅度越大，总外周血管阻力和血压升高幅度越大。血清钙升高还与血浆甲状旁腺激素和肾素活性降低以及血浆醛固酮升高有关，这可能促成了血压升高。我们的结果表明，血清钙水平升高导致钙流入动脉平滑肌，这会增加胞质钙，诱导肌肉收缩，从而产生动脉血管收缩，导致总外周血管阻力和血压升高。
