Garcia Zozaya J L, Padilla Viloria M, Castro A
University of Carabobo School of Medcine, Renal Division, Valencia, Venezuela.
Am J Hypertens. 1988 Oct;1(4 Pt 1):393-6. doi: 10.1093/ajh/1.4.393.
Plasma renin activity, plasma and urinary aldosterone, and serum and urinary calcium and magnesium were studied in forty elderly normotensive subjects and 37 normotensive young adult controls. Arterial tension was also recorded for each subject. The most important findings were significantly lower levels (P less than 0.001) of plasma renin activity, urinary aldosterone, and serum ionic calcium in the elderly group. A significant positive correlation was shown between calcium and plasma renin activity (P less than 0.001); an inverse correlation was found between systolic arterial tension and calcium (P less than 0.001). These findings indicate age-related physiological changes between the renin-aldosterone system, calcium, and systolic arterial tension. These changes are similar to those found previously in young adult hypertensives with low plasma renin activity levels, suggesting that the arterial tension of the elderly is labile, and that changes in the renin-angiotensin-aldosterone system (RAA) and calcium levels directly influence the increase of systolic arterial tension, which is frequently found in the elderly.
对40名老年血压正常者和37名血压正常的年轻成年人对照组进行了血浆肾素活性、血浆和尿醛固酮以及血清和尿钙与镁的研究。还记录了每名受试者的动脉血压。最重要的发现是老年组的血浆肾素活性、尿醛固酮和血清离子钙水平显著降低（P<0.001）。钙与血浆肾素活性之间呈显著正相关（P<0.001）；收缩压与钙之间呈负相关（P<0.001）。这些发现表明肾素-醛固酮系统、钙和收缩压之间存在与年龄相关的生理变化。这些变化与先前在血浆肾素活性水平较低的年轻成年高血压患者中发现的变化相似，提示老年人的动脉血压不稳定，肾素-血管紧张素-醛固酮系统（RAA）和钙水平的变化直接影响收缩压升高，而收缩压升高在老年人中很常见。
