Department of Ophthalmology, Medical College of Georgia, Augusta, Georgia, USA.
Ophthalmology. 2011 Oct;118(10):1927-31. doi: 10.1016/j.ophtha.2011.02.042. Epub 2011 Jun 8.
To evaluate the intraocular pressure (IOP) outcomes of patients with noninfectious posterior uveitis treated with a fluocinolone acetonide (FA) intravitreal implant over an 8-year period.
Retrospective clinical case series.
Forty-seven eyes of 35 patients.
Retrospective review of medical records of all patients receiving FA implants between June 2001 and March 2009 was performed. Data were pooled to record visual acuity (VA) and to characterize the incidence and outcome of glaucoma surgical intervention.
Incidence of glaucoma surgery and IOP before and after glaucoma surgical intervention. Visual acuity before and after FA implant placement.
Nineteen of 42 eyes (45%) receiving FA implants over the course of the study period required glaucoma surgical intervention. Success of IOP-lowering surgery was achieved in 94%, 94%, and 92% of eyes at 6, 12, and 24 months postoperatively. No patient lost more than 1 line of VA. There was an average 2-line gain of acuity at 3 years after FA implant placement for those patients who underwent IOP-lowering surgery.
Patients receiving FA implants have a significant risk of increased IOP that frequently necessitates glaucoma surgery. Glaucoma surgery, when necessary, offers an effective method to decrease IOP.
FINANCIAL DISCLOSURE(S): Proprietary or commercial disclosure may be found after the references.
评估氟轻松醋酸酯（FA）眼内植入物治疗非感染性后葡萄膜炎患者 8 年期间的眼压（IOP）结果。
回顾性临床病例系列。
35 名患者的 47 只眼。
对 2001 年 6 月至 2009 年 3 月期间接受 FA 植入物的所有患者的病历进行回顾性审查。汇总数据记录视力（VA）并描述青光眼手术干预的发生率和结果。
青光眼手术的发生率和青光眼手术前后的 IOP。FA 植入前后的视力。
在研究期间，42 只眼中有 19 只（45%）接受 FA 植入物，需要进行青光眼手术干预。术后 6、12 和 24 个月，降压手术成功率分别为 94%、94%和 92%。没有患者视力损失超过 1 行。在接受 IOP 降低手术的患者中，FA 植入后 3 年平均视力提高了 2 行。
接受 FA 植入物的患者有明显的眼压升高风险，这常常需要进行青光眼手术。当需要时，青光眼手术是降低眼压的有效方法。
参考文献后可能会有专有或商业披露。
