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一位患有高安动脉炎的患者出现严重皮质类固醇诱导的高眼压,需要双侧小梁切除术。

Severe Corticosteroid-Induced Ocular Hypertension Requiring Bilateral Trabeculectomies in a Patient with Takayasu's Arteritis.

作者信息

Gruener Anna Maria, Sharma Pranev, Ameen Sally, Ahmed Faisal

机构信息

Western Eye Hospital, Imperial College Healthcare NHS Trust, London, UK.

出版信息

Case Rep Ophthalmol Med. 2016;2016:5253029. doi: 10.1155/2016/5253029. Epub 2016 Nov 10.

DOI:10.1155/2016/5253029
PMID:27957366
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5121439/
Abstract

We present a rare case of severe corticosteroid-induced ocular hypertension (OHT) after prolonged systemic corticosteroid use in a young woman with Takayasu's arteritis. As she did not sufficiently respond to ocular antihypertensive therapies, bilateral enhanced trabeculectomies were required to normalize her intraocular pressures. The systemic side effects of corticosteroids are well known, yet steroid-induced OHT and glaucoma remain silent causes of ocular morbidity. This case highlights the importance of IOP-monitoring in visually asymptomatic patients on systemic corticosteroids. It further emphasizes the need to raise awareness of the potential ocular side effects of steroids amongst physicians, in particular those looking after patients with autoimmune and inflammatory diseases.

摘要

我们报告了一例罕见病例,一名患有大动脉炎的年轻女性在长期全身使用皮质类固醇后出现严重的皮质类固醇诱导性高眼压(OHT)。由于她对眼部抗高血压治疗反应不佳,需要进行双侧小梁切除术以使其眼压恢复正常。皮质类固醇的全身副作用众所周知,但类固醇诱导的OHT和青光眼仍然是导致眼部发病的隐匿原因。该病例强调了对使用全身皮质类固醇的视觉无症状患者进行眼压监测的重要性。它进一步强调了提高医生,特别是那些照顾自身免疫性和炎性疾病患者的医生对类固醇潜在眼部副作用认识的必要性。

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Severe Corticosteroid-Induced Ocular Hypertension Requiring Bilateral Trabeculectomies in a Patient with Takayasu's Arteritis.一位患有高安动脉炎的患者出现严重皮质类固醇诱导的高眼压,需要双侧小梁切除术。
Case Rep Ophthalmol Med. 2016;2016:5253029. doi: 10.1155/2016/5253029. Epub 2016 Nov 10.
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本文引用的文献

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Steroid-induced ocular hypertension/glaucoma: Focus on pharmacogenomics and implications for precision medicine.类固醇诱导性眼压升高/青光眼:聚焦药物基因组学及其对精准医学的影响
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Goniotomy for Steroid-Induced Glaucoma: Clinical and Tonographic Evidence to Support Therapeutic Goniotomy.用于类固醇性青光眼的前房角切开术:支持治疗性前房角切开术的临床和眼压描记证据
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Animal models of glucocorticoid-induced glaucoma.
糖皮质激素性青光眼的动物模型。
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