Department of Medicine, Metabolic Clinic, Infectious and Tropical Diseases Unit, University of Modena and Reggio Emilia, Modena, Italy.
J Antimicrob Chemother. 2011 Aug;66(8):1857-60. doi: 10.1093/jac/dkr206. Epub 2011 Jun 8.
Cardiovascular risk is increased in HIV-infected individuals compared with the general population, making HIV disease an ideal model to investigate the pathogenesis and natural history of atherosclerosis. In this pilot study, we compared the progression of coronary artery calcium (CAC) between HIV-infected and uninfected patients.
Atherosclerosis progression was assessed in 25 HIV-infected men and 13 HIV-negative controls by means of sequential CAC scans using CT. A CAC score progression ≥ 15%/year was used as a surrogate marker of increased risk of cardiovascular events.
During a median follow-up of 11 months, a CAC score increase ≥ 15%/year was detected in 14 HIV-infected patients (56%) and 4 HIV-negative individuals (31%). HIV infection, age and hypercholesterolaemia were independently associated with a CAC score increase ≥ 15%/year in an adjusted Cox regression model.
HIV infection, age and hypercholesterolaemia were independently associated with CAC progression. HIV as well as traditional risk factors contribute to accelerate atherosclerosis in HIV-infected patients.
与普通人群相比，HIV 感染者的心血管风险增加，这使得 HIV 疾病成为研究动脉粥样硬化发病机制和自然史的理想模型。在这项初步研究中，我们比较了 HIV 感染者和未感染者冠状动脉钙（CAC）的进展情况。
通过 CT 对 25 名 HIV 感染男性和 13 名 HIV 阴性对照者进行了动脉粥样硬化进展评估。CAC 评分进展≥15%/年被用作心血管事件风险增加的替代标志物。
在中位随访 11 个月期间，14 名 HIV 感染者（56%）和 4 名 HIV 阴性个体（31%）检测到 CAC 评分增加≥15%/年。在调整后的 Cox 回归模型中，HIV 感染、年龄和高胆固醇血症与 CAC 评分增加≥15%/年独立相关。
HIV 感染、年龄和高胆固醇血症与 CAC 进展独立相关。HIV 以及传统危险因素都促使 HIV 感染者的动脉粥样硬化加速发展。
