血清中具有交叉中和活性的患者体内人类免疫缺陷病毒 1 型的进化。
Evolution of human immunodeficiency virus type 1 in a patient with cross-reactive neutralizing activity in serum.
机构信息
Department of Experimental Immunology, Academic Medical Center, AZ Amsterdam, The Netherlands.
出版信息
J Virol. 2011 Aug;85(16):8443-8. doi: 10.1128/JVI.05214-11. Epub 2011 Jun 8.
Abstract
Analysis of longitudinally obtained HIV-1 env sequences from an individual with reported cross-reactive neutralizing activity revealed that the majority of viral variants obtained from serum between 4 and 7 years after seroconversion were unable to persist in peripheral blood. Here we show that these viral variants were more sensitive to autologous serum neutralization, had shorter envelopes with fewer potential N-linked glycosylation sites, and showed lower replication kinetics than successfully evolving HIV-1 variants. These data reflect the host selection pressures on phenotypic characteristics of HIV-1 and illustrate in detail the dynamic interaction between HIV-1 and its host's humoral immune responses.
摘要
对一名具有报道称的交叉中和活性的个体进行纵向 HIV-1 env 序列分析，结果表明，在血清转化后 4 至 7 年内从血清中获得的大多数病毒变异体无法在周围血液中持续存在。在这里，我们表明，与成功进化的 HIV-1 变体相比，这些病毒变体对自身血清中和更敏感，包膜更短，潜在的 N-连接糖基化位点更少，复制动力学更低。这些数据反映了宿主对 HIV-1 表型特征的选择压力，并详细说明了 HIV-1 与其宿主体液免疫反应之间的动态相互作用。
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