Department of Pathogenobiology, Jilin University Mycology Research Center, Norman Bethune College of Medicine, Jilin University, Changchun, 130021, China.
Mycopathologia. 2013 Aug;176(1-2):75-81. doi: 10.1007/s11046-013-9667-7. Epub 2013 Jun 6.
Edenia gomezpompae, isolated from a patient suffering from keratitis, who was an agricultural worker with a 4-year history of diabetes mellitus, is described. Fungal hyphae were detected in corneal scrapings after microscopic examination and repeated culture. Isolates were identified by morphology and by sequencing the internal transcribed spacer region of ribosomal DNA. Chlamydospore characteristics of E. gomezpompae are described for the first time. The in vitro antifungal susceptibilities of the isolate were tested using five antifungal agents. With the exception of fluconazole, the other drugs (natamycin, amphotericin B, itraconazole, and voriconazole) assayed were highly effective against this fungus. The keratitis was cured after debridement of the corneal ulcer and treatment with 5 % natamycin. After 3 months, when the patient was reexamined, the corneal ulcer showed signs of healing, with no recurrence. To our knowledge, this is the first reported case of keratitis caused by E. gomezpompae, as well as being the first known case of disease in humans caused by this species.
从一位患有角膜炎的患者的角膜刮片中检测到真菌菌丝，该患者是一名农业工人，患有糖尿病 4 年。经过显微镜检查和反复培养，分离出真菌。通过形态学和核糖体 DNA 内转录间隔区的测序鉴定了分离株。首次描述了埃氏戈梅兹波帕菌的厚垣孢子特征。使用五种抗真菌药物测试了分离株的体外抗真菌药敏性。除氟康唑外，其他测试药物（那他霉素、两性霉素 B、伊曲康唑和伏立康唑）对该真菌均具有高度有效性。角膜溃疡清创和 5%那他霉素治疗后，角膜炎痊愈。3 个月后，当患者再次接受检查时，角膜溃疡显示出愈合迹象，无复发。据我们所知，这是首例由埃氏戈梅兹波帕菌引起的角膜炎病例，也是首例由该物种引起的人类疾病病例。
