Zhang Wei, Wang Huaiyu, Oyane Ayako, Tsurushima Hideo, Chu Paul K
Nanosystem Research Institute, National Institute of Advanced Industrial Science and Technology, Tsukuba, Japan.
Biomed Mater Eng. 2011;21(2):75-82. doi: 10.3233/BME-2011-0657.
Plasma technology is widely employed to tailor the surface chemistry of polymeric biomaterials. In this work, nitrogen-containing functional groups were generated on a polymer surface by N₂ plasma immersion ion implantation (PIII). We evaluated the abilities of the resulting surface to inhibit bacterial growth and to enhance osteoblast differentiation from the perspective of bone tissue engineering. Our results demonstrate that the N₂ PIII-treated polymer surface exhibits antibacterial properties against Escherichia coli. Moreover, the N₂ PIII-treated polymer surface has the ability to enhance differentiation of osteoblasts. N₂ PIII-treated polymer surface may therefore be useful in bone tissue engineering.
等离子体技术被广泛应用于定制聚合物生物材料的表面化学性质。在这项工作中，通过氮气等离子体浸没离子注入（PIII）在聚合物表面生成了含氮官能团。我们从骨组织工程的角度评估了所得表面抑制细菌生长和促进成骨细胞分化的能力。我们的结果表明，经氮气PIII处理的聚合物表面对大肠杆菌具有抗菌性能。此外，经氮气PIII处理的聚合物表面具有促进成骨细胞分化的能力。因此，经氮气PIII处理的聚合物表面可能在骨组织工程中有用。
