葡萄糖介导的三羧酸循环分解代谢阻遏作为自杀性气单胞菌菌株中乙酸产量增加的一种解释。
Glucose-mediated catabolite repression of the tricarboxylic acid cycle as an explanation for increased acetic acid production in suicidal Aeromonas strains.
作者信息
Namdari H, Cabelli V J
机构信息
Department of Microbiology, University of Rhode Island, Kingston 02881.
出版信息
J Bacteriol. 1990 Aug;172(8):4721-4. doi: 10.1128/jb.172.8.4721-4724.1990.
Abstract
Growth in the presence of glucose, even under highly aerobic conditions, significantly reduced the activities of three tricarboxylic acid cycle enzymes, citrate synthetase, alpha-ketoglutarate dehydrogenase, and malate dehydrogenase, in suicidal but not nonsuicidal Aeromonas strains. Pyruvate dehydrogenase activity, however, was significantly increased. The activities of all of the enzymes, as well as the glucose-mediated increase in acetic acid production, were shown to be regulated by catabolite repression. The regulator protein is the same one which regulates the utilization of several sugars.
摘要
在葡萄糖存在的情况下生长，即使是在高度需氧条件下，也会显著降低自杀性气单胞菌菌株（而非非自杀性气单胞菌菌株）中三种三羧酸循环酶（柠檬酸合酶、α-酮戊二酸脱氢酶和苹果酸脱氢酶）的活性。然而，丙酮酸脱氢酶的活性显著增加。所有这些酶的活性，以及葡萄糖介导的乙酸产量增加，均显示受分解代谢物阻遏调控。调节蛋白与调节几种糖类利用的蛋白相同。
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