• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

抗癫痫药物继发的双侧视网膜分支静脉阻塞（疑似）

Presumed bilateral branch retinal vein occlusions secondary to antiepileptic agents.

作者信息

Hussain Rumana N, Banerjee Somnath

机构信息

Leicester Royal Infirmary, Leicester, UK.

出版信息

Clin Ophthalmol. 2011;5:609-11. doi: 10.2147/OPTH.S17754. Epub 2011 May 13.

DOI:10.2147/OPTH.S17754
PMID:21654889
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3102593/
Abstract

A 61-year-old man presented to the ophthalmology department having developed bilateral branch retinal vein occlusions. Baseline blood tests revealed no abnormality; however, subsequent investigations showed a raised plasma homocysteine (HC) level. The patient has been treated for refractory epilepsy for a number of years. Although antiepileptic medications have been shown to reduce folate levels and result in a raised HC level, this has not previously been shown to be to a level causing a retinal vascular event.

摘要

一名61岁男性因双眼视网膜分支静脉阻塞就诊于眼科。基线血液检查未发现异常；然而，后续检查显示血浆同型半胱氨酸（HC）水平升高。该患者多年来一直患有难治性癫痫。尽管抗癫痫药物已被证明会降低叶酸水平并导致HC水平升高，但此前尚未证明会升高到导致视网膜血管事件的水平。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4b96/3102593/504f993d2bf5/opth-5-609f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4b96/3102593/f0368bc7bfe9/opth-5-609f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4b96/3102593/504f993d2bf5/opth-5-609f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4b96/3102593/f0368bc7bfe9/opth-5-609f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4b96/3102593/504f993d2bf5/opth-5-609f2.jpg

相似文献

1
Presumed bilateral branch retinal vein occlusions secondary to antiepileptic agents.抗癫痫药物继发的双侧视网膜分支静脉阻塞（疑似）
Clin Ophthalmol. 2011;5:609-11. doi: 10.2147/OPTH.S17754. Epub 2011 May 13.
2
Plasma total homocysteine and retinal vascular disease.血浆总同型半胱氨酸与视网膜血管疾病。
Eye (Lond). 2000 Aug;14 ( Pt 4):590-3. doi: 10.1038/eye.2000.148.
3
Raised plasma homocysteine as a risk factor for retinal vascular occlusive disease.血浆同型半胱氨酸升高作为视网膜血管阻塞性疾病的一个危险因素。
Br J Ophthalmol. 2000 Feb;84(2):154-7. doi: 10.1136/bjo.84.2.154.
4
Branch Retinal Vein Occlusion in a COVID-19 Positive Patient.一名新冠病毒检测呈阳性患者的视网膜静脉分支阻塞
Cureus. 2021 Feb 27;13(2):e13586. doi: 10.7759/cureus.13586.
5
A case report of branch retinal artery occlusion in a teenager due to hyperhomocysteinaemia; the interplay of genetic and nutritional defects.一名青少年因高同型半胱氨酸血症导致视网膜分支动脉阻塞的病例报告；遗传缺陷与营养缺陷的相互作用
BMC Ophthalmol. 2018 Sep 14;18(Suppl 1):220. doi: 10.1186/s12886-018-0859-2.
6
Meta-analysis of plasma homocysteine, serum folate, serum vitamin B(12), and thermolabile MTHFR genotype as risk factors for retinal vascular occlusive disease.血浆同型半胱氨酸、血清叶酸、血清维生素B12及热不稳定型亚甲基四氢叶酸还原酶（MTHFR）基因型作为视网膜血管阻塞性疾病危险因素的荟萃分析。
Am J Ophthalmol. 2003 Dec;136(6):1136-50. doi: 10.1016/s0002-9394(03)00571-3.
7
One-year outcome of bevacizumab therapy for chronic macular edema in central and branch retinal vein occlusions in real-world clinical practice in the UK.英国真实临床实践中贝伐单抗治疗视网膜中央静脉阻塞和视网膜分支静脉阻塞所致慢性黄斑水肿的一年疗效
Clin Ophthalmol. 2015 Sep 25;9:1779-84. doi: 10.2147/OPTH.S89147. eCollection 2015.
8
ADULT WITH CHICKENPOX COMPLICATED BY SYSTEMIC VASCULITIS AND BILATERAL RETINAL VASCULITIS WITH RETINAL VASCULAR OCCLUSIONS.
Retin Cases Brief Rep. 2017;11(4):364-368. doi: 10.1097/ICB.0000000000000372.
9
Microperimetry as a routine diagnostic test in the follow-up of retinal vein occlusion?微视野检查作为视网膜静脉阻塞随访中的常规诊断测试？
Graefes Arch Clin Exp Ophthalmol. 2012 Feb;250(2):175-83. doi: 10.1007/s00417-011-1784-8. Epub 2011 Aug 27.
10
Bilateral central retinal vein occlusions combined with artery occlusions in a patient with acquired immune deficiency syndrome.一名获得性免疫缺陷综合征患者出现双侧视网膜中央静脉阻塞合并动脉阻塞。
Yan Ke Xue Bao. 2002 Mar;18(1):27-9.

引用本文的文献

1
Bilateral Branch Retinal Vein Occlusion after mRNA-SARS-CoV-2 Booster Dose Vaccination.mRNA-SARS-CoV-2加强剂量疫苗接种后双侧视网膜分支静脉阻塞
J Clin Med. 2023 Feb 7;12(4):1325. doi: 10.3390/jcm12041325.

本文引用的文献

1
Atherosclerotic risk among children taking antiepileptic drugs.服用抗癫痫药物儿童的动脉粥样硬化风险。
Pharmacol Rep. 2009 May-Jun;61(3):411-23. doi: 10.1016/s1734-1140(09)70082-9.
2
Effects of antiepileptic drugs on lipids, homocysteine, and C-reactive protein.抗癫痫药物对脂质、同型半胱氨酸和C反应蛋白的影响。
Ann Neurol. 2009 Apr;65(4):448-56. doi: 10.1002/ana.21615.
3
The effect of antiepileptic drugs on vitamin B12 metabolism.抗癫痫药物对维生素B12代谢的影响。
Int J Lab Hematol. 2008 Feb;30(1):26-35. doi: 10.1111/j.1751-553X.2007.00910.x.
4
[Assessment of risk factors for retinal vein occlusions in patients under 60 years of age].
J Fr Ophtalmol. 2007 Nov;30(9):918-23. doi: 10.1016/s0181-5512(07)74029-9.
5
Hyperhomocysteinemia and central retinal vein occlusion in Iranian population.伊朗人群中的高同型半胱氨酸血症与视网膜中央静脉阻塞
Int Ophthalmol. 2008 Feb;28(1):23-8. doi: 10.1007/s10792-007-9103-4. Epub 2007 Jul 17.
6
Hyperhomocysteinemia and low methionine stress are risk factors for central retinal venous occlusion in an Indian population.高同型半胱氨酸血症和低蛋氨酸应激是印度人群中心视网膜静脉阻塞的危险因素。
Invest Ophthalmol Vis Sci. 2007 Apr;48(4):1441-6. doi: 10.1167/iovs.06-0905.
7
Hyperhomocysteinemia and low plasma folate as risk factors for central retinal vein occlusion: a case-control study in a Chinese population.高同型半胱氨酸血症和低血浆叶酸作为视网膜中央静脉阻塞的危险因素：一项中国人群的病例对照研究
Graefes Arch Clin Exp Ophthalmol. 2006 Oct;244(10):1246-9. doi: 10.1007/s00417-005-0191-4. Epub 2006 Mar 15.
8
The dose-response relation between serum homocysteine and cardiovascular disease: implications for treatment and screening.血清同型半胱氨酸与心血管疾病之间的剂量反应关系：对治疗和筛查的启示。
Eur J Cardiovasc Prev Rehabil. 2004 Jun;11(3):250-3. doi: 10.1097/01.hjr.0000129742.15346.ab.
9
Association between homocyst(e)ine levels and risk of vascular events.
Drugs Today (Barc). 2003 Mar;39(3):175-92. doi: 10.1358/dot.2003.39.3.799452.
10
Hyperhomocyst(e)inemia, but not methylenetetrahydrofolate reductase C677T mutation, as a risk factor in branch retinal vein occlusion.高同型半胱氨酸血症而非亚甲基四氢叶酸还原酶C677T突变是视网膜分支静脉阻塞的危险因素。
Ophthalmology. 2002 Jun;109(6):1105-9. doi: 10.1016/s0161-6420(02)01044-8.