University of Western Ontario, Schulich School of Medicine and Dentistry, London, ON.
Curr Oncol. 2011 Jun;18(3):e158-62. doi: 10.3747/co.v18i3.761.
Rosai-Dorfman disease is a rare lymphoproliferative disorder that can have nodal and extranodal manifestations. In the absence of established guidelines for the management of this condition, various therapeutic modalities are used, including radiotherapy. Radiation dosages and fractionation schedules have not been reported in all instances. We present a case in which glottic and subglottic Rosai-Dorfman lesions causing airway obstruction in a frail steroid-refractory patient were put into complete remission using radiotherapy. The lesions responded transiently to a course of prednisone, but responded completely to external-beam radiation, with minimal side effects to the patient.
罗萨达-多夫曼病是一种罕见的淋巴组织增生性疾病，可表现为淋巴结和结外表现。由于缺乏针对这种疾病的既定管理指南，因此使用了各种治疗方式，包括放射治疗。并非所有情况下都报告了放射剂量和分割方案。我们报告了一例患有罗萨达-多夫曼病的患者，病变位于声门和声门下，导致气道阻塞，该患者体质虚弱且对类固醇治疗无反应，经放射治疗后完全缓解。病变对泼尼松治疗有短暂反应，但对外照射完全反应，对患者的副作用最小。
