Hospital Universitário, Universidade de São Paulo (USP), São Paulo, SP, Brazil.
J Pediatr (Rio J). 2011 Jul-Aug;87(4):307-13. doi: 10.2223/JPED.2100. Epub 2011 Jun 8.
To compare the severity of single respiratory syncytial virus (RSV) infections with that of coinfections.
A historical cohort was studied, including hospitalized infants with acute RSV infection. Nasopharyngeal aspirate samples were collected from all patients to detect eight respiratory viruses using molecular biology techniques. The following outcomes were analyzed: duration of hospitalization and of oxygen therapy, intensive care unit admission and need of mechanical ventilation. Results were adjusted for confounding factors (prematurity, age and breastfeeding).
A hundred and seventy six infants with bronchiolitis and/or pneumonia were included in the study. Their median age was 4.5 months. A hundred and twenty one had single RSV infection and 55 had coinfections (24 RSV + adenovirus, 16 RSV + human metapneumovirus and 15 other less frequent viral associations). The four severity outcomes under study were similar in the group with single RSV infection and in the coinfection groups, independently of what virus was associated with RSV.
Virus coinfections do not seem to affect the prognosis of hospitalized infants with acute RSV infection.
比较单纯呼吸道合胞病毒（RSV）感染与混合感染的严重程度。
本研究采用回顾性队列研究，纳入急性 RSV 感染住院婴儿。所有患者均采集鼻咽抽吸物样本，采用分子生物学技术检测 8 种呼吸道病毒。分析的结局包括住院时间、吸氧时间、入住重症监护病房和需要机械通气。结果调整了混杂因素（早产、年龄和母乳喂养）。
本研究纳入 176 例毛细支气管炎和/或肺炎患儿，中位年龄为 4.5 个月。121 例为单纯 RSV 感染，55 例为混合感染（24 例 RSV+腺病毒，16 例 RSV+人偏肺病毒，15 例其他少见病毒混合感染）。在单纯 RSV 感染组和混合感染组中，与 RSV 相关的病毒不同，四项严重结局相似。
病毒混合感染似乎不会影响急性 RSV 感染住院婴儿的预后。
