Ciccozzi Massimo, Babakir-Mina Muhammed, Lo Presti Alessandra, Marcuccilli Fabbio, Perno Carlo Federico, Ciotti Marco
Department of Infectious, Parasitic and Immunomediated Diseases, Istituto Superiore di Sanita', Rome, Italy.
Open Virol J. 2011;5:22-6. doi: 10.2174/1874357901105010022. Epub 2011 Apr 7.
During the spring of 2009, a new influenza A (H1N1) virus of swine origin emerged and spread worldwide causing a pandemic influenza. Here, 329 naso-pharyngeal swabs collected from patients with flu-like symptoms were analyzed by real-time PCR for the presence of H1N1 2009 pandemic virus. Twenty-five samples collected from immunocompetent and immunodepressed patients contained the H1N1 pandemic virus. Phylogenetic analysis of the hemagglutinin and neuraminidase genes showed no obvious differences in terms of similarity and/or homology between the sequences identified in immunocompetent individuals and those obtained from immunocompromised patients. Pre-existing clinical conditions may influence the outcome of H1N1 disease.
2009年春季，一种源自猪的新型甲型H1N1流感病毒出现并在全球传播，引发了一场大流行性流感。在此，对从有流感样症状患者中采集的329份鼻咽拭子进行实时PCR分析，以检测2009年甲型H1N1大流行病毒的存在。从免疫功能正常和免疫功能低下患者中采集的25份样本含有甲型H1N1大流行病毒。血凝素和神经氨酸酶基因的系统发育分析表明，免疫功能正常个体中鉴定出的序列与免疫功能低下患者中获得的序列在相似性和/或同源性方面没有明显差异。先前存在的临床状况可能会影响甲型H1N1疾病的结局。
