猪源2009甲型（H1N1）流感病毒在雪貂体内的发病机制与传播
Pathogenesis and transmission of swine-origin 2009 A(H1N1) influenza virus in ferrets.
作者信息
Munster Vincent J, de Wit Emmie, van den Brand Judith M A, Herfst Sander, Schrauwen Eefje J A, Bestebroer Theo M, van de Vijver David, Boucher Charles A, Koopmans Marion, Rimmelzwaan Guus F, Kuiken Thijs, Osterhaus Albert D M E, Fouchier Ron A M
机构信息
National Influenza Center and Department of Virology, Erasmus Medical Center, 3015GE Rotterdam, The Netherlands.
出版信息
Science. 2009 Jul 24;325(5939):481-3. doi: 10.1126/science.1177127. Epub 2009 Jul 2.
Abstract
The swine-origin A(H1N1) influenza virus that has emerged in humans in early 2009 has raised concerns about pandemic developments. In a ferret pathogenesis and transmission model, the 2009 A(H1N1) influenza virus was found to be more pathogenic than a seasonal A(H1N1) virus, with more extensive virus replication occurring in the respiratory tract. Replication of seasonal A(H1N1) virus was confined to the nasal cavity of ferrets, but the 2009 A(H1N1) influenza virus also replicated in the trachea, bronchi, and bronchioles. Virus shedding was more abundant from the upper respiratory tract for 2009 A(H1N1) influenza virus as compared with seasonal virus, and transmission via aerosol or respiratory droplets was equally efficient. These data suggest that the 2009 A(H1N1) influenza virus has the ability to persist in the human population, potentially with more severe clinical consequences.
摘要
2009年初在人群中出现的猪源A(H1N1)流感病毒引发了对大流行发展的担忧。在雪貂发病机制和传播模型中，发现2009年A(H1N1)流感病毒比季节性A(H1N1)病毒更具致病性，在呼吸道中发生更广泛的病毒复制。季节性A(H1N1)病毒的复制局限于雪貂的鼻腔，但2009年A(H1N1)流感病毒也在气管、支气管和细支气管中复制。与季节性病毒相比，2009年A(H1N1)流感病毒从上呼吸道排出的病毒更多，并且通过气溶胶或呼吸道飞沫传播的效率相同。这些数据表明，2009年A(H1N1)流感病毒有能力在人群中持续存在，可能会带来更严重的临床后果。
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