Fryburg Karsten, Nguyen Ha Son, Cohen-Gadol Aaron A
St. Francis Hospital, Division of Neurological Surgery, Department of Neurological Surgery, Indiana University, Indianapolis, IN, USA.
Surg Neurol Int. 2011;2:44. doi: 10.4103/2152-7806.79759. Epub 2011 Apr 19.
Spontaneous acute subdural hematomas (SDHs) are rare. Risk factors for development of these hematomas include conditions such as hypertension, vascular abnormalities such as aneurysm or arteriovenous malformation, or consumption of anticoagulants.
Here, the authors report two patients who suffered from spontaneous acute SDH while taking fondaparinux for venous thromboembolism prophylaxis. One patient suffered from a remote episode of traumatic brain injury and underwent a decompressive craniectomy 3 weeks prior to presentation, whereas the other patient had been self-medicating with aspirin.
To our knowledge, these two patients illustrate the first cases of spontaneous acute SDH formation most likely attributed to consumption of fondaparinux.
自发性急性硬膜下血肿（SDH）较为罕见。这些血肿形成的危险因素包括高血压等病症、动脉瘤或动静脉畸形等血管异常情况，或服用抗凝剂。
在此，作者报告了两名在服用磺达肝癸钠预防静脉血栓栓塞时发生自发性急性SDH的患者。一名患者曾有过颅脑外伤史，并在就诊前3周接受了减压颅骨切除术，而另一名患者一直在自行服用阿司匹林。
据我们所知，这两名患者是首例自发性急性SDH形成最可能归因于服用磺达肝癸钠的病例。
