经颅磁刺激诱发运动电位的个体内变异性和相关性。
Intra subject variation and correlation of motor potentials evoked by transcranial magnetic stimulation.
机构信息
Statistics Department, University College Cork, Cork, Ireland.
出版信息
Ir J Med Sci. 2011 Dec;180(4):873-80. doi: 10.1007/s11845-011-0722-4. Epub 2011 Jun 10.
BACKGROUND
Characterising intra and inter-subject variability of motor-evoked potential (MEP) measurements from transcranial magnetic stimulation (TMS) is key to its development as a diagnostic tool.
METHODS
We performed three experiments to elucidate MEP variability within subjects: (i) repeated measurements at different levels of stimulation and muscle activation, (ii) simultaneous measurements at pairs of ipsilateral and contralateral muscles, (iii) simultaneous measurements of contralateral muscles when one is activated.
RESULTS
Cube root transformation of MEP data produces approximately constant coefficient of variation with Gaussian distribution and no significant autocorrelation between repeat measurements. After adjustment of intersubject variability, correlation between simultaneous muscle pairs was insignificant (p = 0.36). Highly significant effects were observed due to increase in intensity of stimulation: (0.07, 0.23) mV, p < 0.0001, muscle type: (p < 0.009) and activation of ipsilateral muscle: (0.10, 0.49) mV, p < 0.0001.
CONCLUSION
Corticospinal effect is dominated by intersubject variability in simultaneous measurements on normal population.
背景
从经颅磁刺激（TMS）中描述运动诱发电位（MEP）测量的个体内和个体间变异性是将其发展为诊断工具的关键。
方法
我们进行了三项实验来阐明MEP 在个体内的变异性：（i）在不同刺激和肌肉激活水平下进行重复测量，（ii）在同侧和对侧肌肉对同时进行测量，（iii）当一侧肌肉被激活时同时测量对侧肌肉。
结果
MEP 数据的立方根转换产生了具有高斯分布的近似恒定变异系数，并且重复测量之间没有显著的自相关。在调整了个体间变异性后，同时测量的肌肉对之间的相关性不显著（p = 0.36）。由于刺激强度的增加而观察到了非常显著的效果：（0.07，0.23）mV，p < 0.0001，肌肉类型：（p < 0.009）和同侧肌肉的激活：（0.10，0.49）mV，p < 0.0001。
结论
在正常人群中同时测量时，皮质脊髓效应主要受个体间变异性的影响。
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