Medical Biotechnology, VTT Technical Research Center of Finland, Turku FI-20520, Finland.
Annu Rev Cell Dev Biol. 2011;27:291-320. doi: 10.1146/annurev-cellbio-092910-154017. Epub 2011 Jun 10.
All multicellular animals express receptors for growth factors (GFs) and extracellular matrix (ECM) molecules. Integrin-type ECM receptors anchor cells to their surroundings and concomitantly activate intracellular signal transduction pathways. The same signaling mechanisms are regulated by GF receptors (GFRs). Recently, intensive research efforts have revealed novel mechanisms describing how the two receptor systems collaborate at many different levels. Integrins can directly bind to GFs and promote their activation. Adhesion receptors also organize signaling platforms and assist GFRs or even activate them via ligand-independent mechanisms. Furthermore, integrins can orchestrate endocytosis and recycling of GFRs. Here, we review the present knowledge about the interplay between integrins and GFRs and discuss recent ideas of how this collaboration may explain some previous controversies in integrin research.
所有多细胞动物都表达生长因子 (GFs) 和细胞外基质 (ECM) 分子的受体。整联蛋白型 ECM 受体将细胞锚定在其周围，并同时激活细胞内信号转导途径。GF 受体 (GFRs) 调节相同的信号机制。最近，大量的研究努力揭示了描述这两个受体系统如何在许多不同层面上相互协作的新机制。整联蛋白可以直接结合 GFs 并促进其激活。黏附受体还组织信号转导平台，并通过非配体依赖机制协助 GFR 甚至激活它们。此外，整联蛋白可以协调 GFR 的内吞作用和循环。在这里，我们回顾了整合素和 GFR 之间相互作用的现有知识，并讨论了这种协作如何解释整合素研究中一些先前争议的新观点。
