Centre for Addiction and Mental Health, Toronto, ON M5T 1R8, Canada.
Mol Brain. 2011 Jun 13;4:26. doi: 10.1186/1756-6606-4-26.
Dopamine is an important catecholamine neurotransmitter modulating many physiological functions, and is linked to psychopathology of many diseases such as schizophrenia and drug addiction. Dopamine D1 and D2 receptors are the most abundant dopaminergic receptors in the striatum, and although a clear segregation between the pathways expressing these two receptors has been reported in certain subregions, the presence of D1-D2 receptor heteromers within a unique subset of neurons, forming a novel signaling transducing functional entity has been shown. Recently, significant progress has been made in elucidating the signaling pathways activated by the D1-D2 receptor heteromer and their potential physiological relevance.
多巴胺是一种重要的儿茶酚胺神经递质，调节许多生理功能，与许多疾病的精神病理学有关，如精神分裂症和药物成瘾。多巴胺 D1 和 D2 受体是纹状体中最丰富的多巴胺能受体，尽管已经在某些亚区报道了表达这两种受体的途径之间的明显分离，但在一组独特的神经元中存在 D1-D2 受体异源二聚体，形成一种新型信号转导功能实体已经被证明。最近，在阐明 D1-D2 受体异源二聚体激活的信号通路及其潜在的生理相关性方面取得了重大进展。
