富含半胱氨酸蛋白 61 的表达与食管鳞癌患者的预后不良相关。

Expression of cysteine-rich 61 is correlated with poor prognosis in patients with esophageal squamous cell carcinoma.

机构信息

Department of Biochemistry and Molecular Biology, Medical College of Shantou University, Shantou 515041, PR China.

出版信息

Eur J Surg Oncol. 2011 Aug;37(8):669-74. doi: 10.1016/j.ejso.2011.05.009. Epub 2011 Jun 12.

DOI:10.1016/j.ejso.2011.05.009

PMID:21664098

Abstract

INTRODUCTION

Cysteine-rich 61 (Cyr61), a secreted protein belonged to the CCN family, was involved in the progression of many cancers. The purpose of this study was to explore the clinical significance of Cyr61 expression in esophageal squamous cell carcinoma (ESCC).

MATERIALS AND METHODS

Cyr61 expression was detected on tissue microarrays of ESCC samples in 372 cases by using immunohistochemical staining. Survival analysis was assessed by the Kaplan-Meier analysis. Relative risk was evaluated by the multivariate Cox proportional hazards model.

RESULTS

The staining pattern of Cyr61 was heterogeneous and varied from negative to intense expression in a cytoplasmic distribution. Kaplan-Meier analysis revealed that expression of Cyr61 was related to poor survival of ESCC patients (P = 0.001). Further analysis revealed that Cyr61 high-expression was related to poorer overall survival of patients in stage I/II (P = 0.001); but did not effect the overall survival of patients in stage III/IV. Univariate and multivariate analysis suggested that Cyr61 expression status was an independent prognostic factor for ESCC (P = 0.001).

DISCUSSION

Cyr61 might play important roles in the progression of ESCC. Cyr61 is a new biomarker to predict the prognosis of ESCC patients.

摘要

简介

富含半胱氨酸的 61 型（Cyr61）是一种分泌型蛋白，属于 CCN 家族，参与了许多癌症的进展。本研究旨在探讨 Cyr61 表达在食管鳞状细胞癌（ESCC）中的临床意义。

材料与方法

通过免疫组织化学染色，在 372 例 ESCC 样本的组织微阵列上检测 Cyr61 的表达。通过 Kaplan-Meier 分析评估生存分析。通过多变量 Cox 比例风险模型评估相对风险。

结果

Cyr61 的染色模式不均匀，从阴性到细胞质分布的强表达不等。Kaplan-Meier 分析表明，Cyr61 的表达与 ESCC 患者的不良生存相关（P = 0.001）。进一步的分析表明，Cyr61 高表达与 I/II 期患者的总生存率较差相关（P = 0.001）；但对 III/IV 期患者的总生存率没有影响。单因素和多因素分析表明，Cyr61 表达状态是 ESCC 的独立预后因素（P = 0.001）。