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KALRN 区域内遗传变异与缺血性脑卒中之间缺乏关联。

Lack of association between genetic variations in the KALRN region and ischemic stroke.

机构信息

Department of Clinical Neuroscience and Rehabilitation, Institute of Neuroscience and Physiology, Sahlgrenska Academy at University of Gothenburg, Sweden.

出版信息

Clin Biochem. 2011 Aug;44(12):1018-20. doi: 10.1016/j.clinbiochem.2011.05.025. Epub 2011 Jun 6.

DOI:10.1016/j.clinbiochem.2011.05.025
PMID:21664346
Abstract

OBJECTIVES

To investigate whether KALRN gene variation is associated with ischemic stroke (IS).

DESIGN AND METHODS

Associations to overall IS and IS subtypes were investigated in SAHLSIS, which comprises 844 patients with IS and 668 controls.

RESULTS

Associations between KALRN SNPs and overall IS and cardioembolic stroke were detected. Associations for overall IS were investigated in two additional Swedish samples, but could not be replicated.

CONCLUSION

KALRN gene variation is not associated with overall IS.

摘要

目的

研究 KALRN 基因突变是否与缺血性脑卒中（IS）有关。

设计与方法

对包含 844 例 IS 患者和 668 例对照的 SAHLSIS 进行了全因 IS 和 IS 亚型的相关性研究。

结果

发现 KALRN SNP 与全因 IS 和心源性脑栓塞相关。在另外两个瑞典样本中对全因 IS 的关联进行了研究，但未能得到重复。

结论

KALRN 基因突变与全因 IS 无关。

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