Fung Manyan, Xue Xiaoqing, Szilagyi Andrew
Lady Davis Institute for Medical Research, Division of Gastroenterology, Sir Mortimer B. Davis Jewish General Hospital, Montréal, Québec, Canada.
Department of Emergency Medicine, Sir Mortimer B. Davis Jewish General Hospital, Montréal, Québec, Canada.
J Can Assoc Gastroenterol. 2020 Jun;3(3):103-110. doi: 10.1093/jcag/gwy068. Epub 2018 Nov 28.
The lactase persistence/nonpersistence (LP/LNP) phenotypes follow a geographic pattern that is rooted in the gene-culture coevolution observed throughout the history of human migrations. The immense size and relatively open immigration policy have drawn migrants of diverse ethnicities to Canada. Among the multicultural demographic, two-thirds of the population are derived from the British Isles and northwestern France. A recent assessment of worldwide lactase distributions found Canada to have an LNP rate of 59% (confidence interval [CI] 44%-74%). This estimate is rather high compared with earlier reports that listed Canada as a country with a 10% LNP rate; the authors had also noted that biases were likely because their calculations were based largely on Aboriginal studies. We hereby present an alternate LNP prevalence estimate at the national, provincial and territorial level.
We applied the referenced LNP frequency distribution data to the 2016 population census to account for the current multi-ethnic distributions in Canada. Prevalence rates for Canada, the provinces and territories were calculated.
The national LNP rate is estimated at 44% (CI 41%-47%) after accounting for the 254 ethnic groups, with the lowest rates found in the eastern provinces and the highest rates in the Northwest Territories (57%) and Nunavut (66%), respectively.
Despite the heterogeneous nature of the referenced data and the inference measures taken, evidently, the validity of our LNP estimate is anchored on the inclusion of multi-ethnic groups representing the current Canadian demographic.
乳糖酶持久性/非持久性（LP/LNP）表型遵循一种地理分布模式，这种模式源于人类迁徙历史中观察到的基因-文化共同进化。加拿大因其庞大的规模和相对开放的移民政策，吸引了来自不同种族的移民。在多元文化人口中，三分之二的人口来自不列颠群岛和法国西北部。最近一项对全球乳糖酶分布的评估发现，加拿大的LNP率为59%（置信区间[CI]44%-74%）。与早期报告将加拿大列为LNP率为10%的国家相比，这一估计相当高；作者还指出，可能存在偏差，因为他们的计算主要基于对原住民的研究。我们在此给出国家、省和地区层面LNP患病率的另一种估计。
我们将参考的LNP频率分布数据应用于2016年人口普查，以考虑加拿大目前的多民族分布情况。计算了加拿大、各省和地区的患病率。
在考虑了254个种族群体后，全国LNP率估计为44%（CI 41%-47%），东部省份的LNP率最低，西北地区（57%）和努纳武特地区（66%）的LNP率最高。
尽管参考数据具有异质性且采取了推断措施，但显然，我们对LNP的估计有效性基于纳入了代表当前加拿大人口结构的多民族群体。
