Hasse J
Division of Thoracic Surgery, University Hospital of Freiburg, Federal Republic of Germany.
Lung. 1990;168 Suppl:1145-52. doi: 10.1007/BF02718255.
Two groups of lung cancer patients with solitary M1 disease are presented in whom lung resection was performed at the time of or after operative treatment of the metastasis. Nine patients had solitary brain metastasis prior to the resection of the primary tumor. Six died, with an average survival of 10 months post-thoracotomy, 3 survive after 15 to 31 months. The results are less favorable than suggested by the literature where often cases are included which have brain metastasis after lung cancer surgery. Another eight M1 situations in this series are predominantly lung cancers with pleural disease. Improvement of quality of life and substantial survival times have been observed, though most patients are still at risk after a survival of from 15 to 35 months. As to the histological features, adenocarcinoma was the most frequent type followed by the adenosquamous variant. Lung surgery should be considered in selected cases in spite of known or formerly treated solitary distant metastasis.
本文介绍了两组患有孤立性M1期疾病的肺癌患者，他们在转移灶手术治疗时或之后接受了肺切除术。9例患者在原发性肿瘤切除术前有孤立性脑转移。6例死亡，开胸术后平均生存10个月，3例在15至31个月后存活。结果比文献报道的要差，文献中常常纳入肺癌手术后出现脑转移的病例。本系列中的另外8例M1期情况主要是伴有胸膜疾病的肺癌。尽管大多数患者在存活15至35个月后仍有风险，但已观察到生活质量有所改善，生存时间显著延长。至于组织学特征，腺癌是最常见的类型，其次是腺鳞癌变体。尽管已知或既往有孤立性远处转移，但在某些选定病例中仍应考虑肺手术。
