Deviri E, Schachner A, Halevy A, Shalit M, Levy M J
Cancer. 1983 Oct 15;52(8):1507-9. doi: 10.1002/1097-0142(19831015)52:8<1507::aid-cncr2820520829>3.0.co;2-z.
During the years 1975 to 1980, 10 male patients and 1 female, with ages ranging between 40 to 61 years, underwent combined resection of primary lung cancer and solitary brain metastasis. In 8 patients the lung cancer was diagnosed and treated first. In those patients, craniotomy for removal of a solitary brain metastasis was carried out 8 to 60 months (mean, 27 months) after excision of the lung tumor. In 3 patients, brain metastasis was diagnosed and treated first and lung excision followed, 2 to 4 weeks after craniotomy. The most common histologic type of the tumor was adenocarcinoma (63.6%). There were no operative deaths. Three patients survived less than 6 months after surgery and were considered as a failure of surgical treatment. Seven patients lived longer than 1 year and three of them are still alive with a follow-up period between 2 to 3 1/2 years after both operations. One of the patients underwent recently successfully second brain intervention for removal of recurrent histologically identical solitary brain metastasis and is well. Our results and those reported in literature encourage the combined surgical removal of primary lung cancer and a solitary brain metastasis.
1975年至1980年期间，10名男性患者和1名女性患者，年龄在40至61岁之间，接受了原发性肺癌合并孤立性脑转移瘤的联合切除术。8例患者先诊断并治疗肺癌，在这些患者中，切除肺肿瘤后8至60个月（平均27个月）进行开颅手术切除孤立性脑转移瘤。3例患者先诊断并治疗脑转移瘤，开颅术后2至4周进行肺切除术。肿瘤最常见的组织学类型是腺癌（63.6%）。无手术死亡病例。3例患者术后存活不到6个月，被视为手术治疗失败。7例患者存活超过1年，其中3例仍存活，两次手术后随访期为2至3.5年。其中1例患者最近成功接受了第二次脑部手术，切除组织学上相同的复发性孤立性脑转移瘤，目前情况良好。我们的结果以及文献报道的结果均支持对原发性肺癌合并孤立性脑转移瘤进行联合手术切除。
